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The catalyst free synthesis of dibenzo[a,j]acridine and its applications in bioimaging of BF3 in HeLa cells
Methods ( IF 4.2 ) Pub Date : 2023-11-30 , DOI: 10.1016/j.ymeth.2023.11.012
Saravanan Enbanathan 1 , Kulathu Iyer Sathiyanarayanan 1
Affiliation  

In this paper, we discuss how tetrahydrodibenzo[a,j]acridine (4-HA) loses its hydrogen, which makes dibenzo[a,j]acridine (ARM) and also how 4-HA can be synthesized effectively using 2-tetralone in high yield. Dehydrogenative condensation and dehydrogenation are the two processes that make up the overall reaction of this synthetic approach. In addition, the presence of BF3 caused a remarkable fluorescence shift in ARM. Test paper analysis was used for examining the practical usefulness of ARM, which can be seen under UV light, resulting in this unique phenomenon. The fluorescent bio imaging experiment demonstrates that the sensor ARM has the capability to detect BF3 in living HeLa cells.



中文翻译:


二苯并[a,j]吖啶的无催化剂合成及其在HeLa细胞BF3生物成像中的应用



在本文中,我们讨论了四氢二苯并[ a,j ]吖啶( 4-HA )如何失去氢,从而生成二苯并[ a,j ]吖啶( ARM ),以及如何使用2-四氢萘酮有效合成4-HA高产。脱氢缩合和脱氢是构成该合成方法总反应的两个过程。此外,BF 3的存在引起ARM中显着的荧光偏移。通过试纸分析来检验ARM的实际用途,在紫外光下可以看到ARM,从而产生了这种独特的现象。荧光生物成像实验表明传感器ARM具有检测活HeLa细胞中BF 3 的能力。

更新日期:2023-11-30
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