The macrodaphniphyllamine-type, calyciphylline A-type, daphnilongeranin A-type, and daphnicyclidin D-type alkaloids are four structurally related classes of Daphniphyllum alkaloids. On the basis of a systematic analysis of the biogenetic network of these classes, we developed synthetic strategies centered on the C4–N and C1–C8 bonds of calyciphylline A, which took full advantage of the suitable substrates, reactions, and pathways that are altered from their counterparts in the postulated biogenetic network. Through this generalized biomimetic approach, we achieved the first synthesis of 14 Daphniphyllum alkaloids from the four subfamilies.

中文翻译：

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四类瑞香生物碱的全合成


大瑞香胺型、金盏花碱 A 型、瑞香 A 型和瑞环素 D 型生物碱是四类结构相关的瑞香生物碱。在对这些类别的生物遗传网络进行系统分析的基础上，我们开发了以calyciphylline A的C4-N和C1-C8键为中心的合成策略，该策略充分利用了合适的底物、反应和被改变的途径来自假定的生物遗传网络中的对应物。通过这种广义的仿生方法，我们首次合成了来自四个亚科的 14 种瑞香生物碱。