Differences in Absorption and Metabolism between Structured 1,3-Oleate-2-palmitate Glycerol and 1-Oleate-2-palmitate-3-linoleate Glycerol on C57BL/6J Mice,Journal of Agricultural and Food Chemistry

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Differences in Absorption and Metabolism between Structured 1,3-Oleate-2-palmitate Glycerol and 1-Oleate-2-palmitate-3-linoleate Glycerol on C57BL/6J Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-12-01 , DOI: 10.1021/acs.jafc.3c07234
Teng Wei ₁ , Dengfeng Tan ₁ , Shengyue Zhong ₁ , Hong Zhang ₂ , Zeyuan Deng ₁ , Jing Li ₁

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This study investigated differences in absorption and metabolism between 1,3-oleate-2-palmitate glycerol (OPO) and 1-oleate-2-palmitate-3-linoleate glycerol (OPL) using C57BL/6J mice. OPL was associated with higher postprandial plasma total triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C) concentrations, and the ratio of LDL-C to high-density lipoprotein cholesterol (HDL-C) compared to those of OPO (p > 0.05). OPO significantly increased postprandial oleic acid (OA) concentrations compared to OPL over the entire monitoring period (p < 0.05), while OPL significantly elevated linoleic acid (LA) levels compared to OPO (p < 0.05). After 1 month of feeding, the mice in both OPO and OPL groups showed lower final weight, weight gain, and liver TG, LDL-C, and LDL/HDL concentrations compared to the control (soybean oil) group. Lipidomics results showed that OPO increased the biosynthesis of very long-chain fatty acids and decreased the abundance of AcCa (16:1), AcCa (18:2), AcCa (18:1), AcCa (16:0), CarE (16:0), and CarE (16:1) relative to OPL. These lipid metabolites were positively correlated with liver TG, LDL-C, and LDL/HDL levels and negatively related to peroxisome proliferator-activated receptors α (PPARα) and acyl-CoA oxidase (ACOX1) expression. This study showed differences in physiologic functions between OPO and OPL and provided support for the future application of OPL in infant formula.

中文翻译：

C57BL/6J 小鼠结构 1,3-油酸酯-2-棕榈酸酯甘油和 1-油酸酯-2-棕榈酸酯-3-亚油酸酯甘油的吸收和代谢差异

本研究使用 C57BL/6J 小鼠研究了 1,3-油酸酯-2-棕榈酸酯甘油 (OPO) 和 1-油酸酯-2-棕榈酸酯-3-亚油酸酯甘油 (OPL) 吸收和代谢的差异。与OPO 相比，OPL 与较高的餐后血浆总三酰甘油 (TG)、低密度脂蛋白胆固醇 (LDL-C) 浓度以及 LDL-C 与高密度脂蛋白胆固醇 (HDL-C) 的比率相关。 > 0.05）。在整个监测期间，与 OPL 相比，OPO 显着增加餐后油酸 (OA) 浓度 ( p < 0.05)，而与 OPO 相比，OPL 显着升高亚油酸 (LA) 水平 ( p < 0.05)。喂养 1 个月后，与对照组（豆油）组相比，OPO 和 OPL 组的小鼠最终体重、体重增加以及肝脏 TG、LDL-C 和 LDL/HDL 浓度均较低。脂质组学结果表明，OPO 增加了极长链脂肪酸的生物合成，并降低了 AccCa (16:1)、AcCa (18:2)、AcCa (18:1)、AcCa (16:0)、CarE 的丰度（ 16:0) 和 CarE (16:1) 相对于 OPL。这些脂质代谢物与肝脏TG、LDL-C和LDL/HDL水平呈正相关，与过氧化物酶体增殖物激活受体α（PPARα）和酰基辅酶A氧化酶（ACOX1）表达呈负相关。本研究揭示了OPO和OPL生理功能的差异，为OPL未来在婴儿配方奶粉中的应用提供支持。

更新日期：2023-12-01

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