Cell Death Discovery ( IF 6.1 ) Pub Date : 2023-12-01 , DOI: 10.1038/s41420-023-01730-5
Yidian Wang 1 , Shouye Hu 1 , Weisong Zhang 1 , Binfei Zhang 1 , Zhi Yang 1
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Lower back pain (LBP) is a common degenerative musculoskeletal disease that imposes a huge economic burden on both individuals and society. With the aggravation of social aging, the incidence of LBP has increased globally. Intervertebral disc degeneration (IDD) is the primary cause of LBP. Currently, IDD treatment strategies include physiotherapy, medication, and surgery; however, none can address the root cause by ending the degeneration of intervertebral discs (IVDs). However, in recent years, targeted therapy based on specific molecules has brought hope for treating IDD. The tumor suppressor gene p53 produces a transcription factor that regulates cell metabolism and survival. Recently, p53 was shown to play an important role in maintaining IVD microenvironment homeostasis by regulating IVD cell senescence, apoptosis, and metabolism by activating downstream target genes. This study reviews research progress regarding the potential role of p53 in IDD and discusses the challenges of targeting p53 in the treatment of IDD. This review will help to elucidate the pathogenesis of IDD and provide insights for the future development of precision treatments.
中文翻译:
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p53 在椎间盘退变中的新作用和治疗意义
腰痛(LBP)是一种常见的退行性肌肉骨骼疾病,给个人和社会带来巨大的经济负担。随着社会老龄化的加剧,LBP的发病率在全球范围内呈上升趋势。椎间盘退变(IDD)是 LBP 的主要原因。目前,IDD的治疗策略包括物理治疗、药物治疗和手术治疗;然而,没有人能够通过结束椎间盘(IVD)的退变来解决根本原因。然而近年来,基于特定分子的靶向治疗为治疗IDD带来了希望。肿瘤抑制基因 p53 产生调节细胞代谢和存活的转录因子。最近,p53被证明通过激活下游靶基因来调节IVD细胞衰老、凋亡和代谢,在维持IVD微环境稳态中发挥重要作用。本研究回顾了 p53 在 IDD 中的潜在作用的研究进展,并讨论了靶向 p53 在 IDD 治疗中面临的挑战。该综述将有助于阐明IDD的发病机制,并为精准治疗的未来发展提供见解。