Enantioselective Synthesis of Axially Chiral Diaryl Ethers via NHC Catalyzed Desymmetrization and Following Resolution,Angewandte Chemie International Edition

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Enantioselective Synthesis of Axially Chiral Diaryl Ethers via NHC Catalyzed Desymmetrization and Following Resolution
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-29 , DOI: 10.1002/anie.202314228
Bang-An Zhou _{1,

2} , Xue-Ning Li ₂ , Chun-Lin Zhang ₁ , Zhi-Xiang Wang ₂ , Song Ye _{1,

2}

Affiliation

The NHC-catalyzed enantioselective synthesis of axially chiral diaryl ethers was developed via desymmetrization of prochiral 2- aryloxyisophthalaldehydes. Mechanistic studies indicate that this process involves NHC-catalyzed desymmetrization followed by kinetic resolution sequence. The utility of this methodology was demonstrated through a broad scope and completed by further late-stage functionalization.

中文翻译：

通过 NHC 催化去对称和后续拆分对映选择性合成轴向手性二芳基醚

通过前手性 2-芳氧基间苯二醛的去对称化，开发了 NHC 催化的对映选择性合成轴向手性二芳基醚。机理研究表明，该过程涉及 NHC 催化的去对称化，然后是动力学拆分序列。这种方法的实用性通过广泛的范围得到了证明，并通过进一步的后期功能化得以完成。

更新日期：2023-11-29

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