The marine bacteria of the Vibrionaceae family are significant from the point of view of their role in the marine geochemical cycle, as well as symbionts and opportunistic pathogens of aquatic animals and humans. The well-known pathogens of this group, Vibrio cholerae, V. parahaemolyticus, and V. vulnificus, are responsible for significant morbidity and mortality associated with a range of infections from gastroenteritis to bacteremia acquired through the consumption of raw or undercooked seafood and exposure to seawater containing these pathogens. Although generally regarded as susceptible to commonly employed antibiotics, the antimicrobial resistance of Vibrio spp. has been on the rise in the last two decades, which has raised concern about future infections by these bacteria becoming increasingly challenging to treat. Diverse mechanisms of antimicrobial resistance have been discovered in pathogenic vibrios, the most important being the membrane efflux pumps, which contribute to antimicrobial resistance and their virulence, environmental fitness, and persistence through biofilm formation and quorum sensing. In this review, we discuss the evolution of antimicrobial resistance in pathogenic vibrios and some of the well-characterized efflux pumps’ contributions to the physiology of antimicrobial resistance, host and environment survival, and their pathogenicity.

从弧菌科海洋细菌在海洋地球化学循环中的作用以及水生动物和人类的共生体和机会病原体的角度来看，它们具有重要意义。该组众所周知的病原体，霍乱弧菌、副溶血弧菌和创伤弧菌，是导致胃肠炎、菌血症等一系列感染相关的重大发病率和死亡率的原因，这些感染是通过食用生的或未煮熟的海鲜以及接触海鲜而获得的。含有这些病原体的海水。尽管普遍认为对常用抗生素敏感，但弧菌属的抗菌素耐药性。在过去的二十年里，这种细菌的感染率呈上升趋势，这引起了人们对这些细菌未来感染变得越来越难以治疗的担忧。在致病性弧菌中发现了多种抗菌药物耐药性机制，其中最重要的是膜外排泵，它通过生物膜形成和群体感应促进抗菌药物耐药性及其毒力、环境适应性和持久性。在这篇综述中，我们讨论了致病性弧菌中抗菌素耐药性的演变，以及一些特征明确的外排泵对抗菌素耐药性生理学、宿主和环境生存及其致病性的贡献。