This review article provides an overview of the green synthesis of thiazole derivatives, emphasizing sustainable and environmentally friendly methodologies. Thiazole derivatives possess significant value and find diverse applications across various fields. However, conventional synthesis methods often involve hazardous reagents and generate substantial waste, posing environmental concerns. The green synthesis of thiazole derivatives employs renewable starting materials, nontoxic catalysts, and mild reaction conditions to minimize environmental impact. Innovative techniques such as microwave irradiation, ultrasound synthesis, green solvents, a green catalyst-based approach, and mechanochemistry-mediated synthesis are employed, offering advantages in terms of scalability, cost-effectiveness, and purification simplicity. The resulting thiazole derivatives exhibit comparable or enhanced biological activities, showcasing the feasibility and practicality of green synthesis in drug discovery. This review paper underscores the importance of sustainable approaches in functional molecular synthesis and encourages further research in this domain.

中文翻译：

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噻唑及其衍生物的新兴绿色合成路线：当前前景

这篇综述文章概述了噻唑衍生物的绿色合成，强调可持续和环境友好的方法。噻唑衍生物具有重要的价值，并在各个领域都有广泛的应用。然而，传统的合成方法通常涉及危险试剂并产生大量废物，造成环境问题。噻唑衍生物的绿色合成采用可再生的原材料、无毒的催化剂和温和的反应条件，以最大限度地减少对环境的影响。采用微波辐射、超声合成、绿色溶剂、绿色催化剂方法和机械化学介导的合成等创新技术，在可扩展性、成本效益和纯化简单性方面具有优势。所得噻唑衍生物表现出相当或增强的生物活性，展示了绿色合成在药物发现中的可行性和实用性。这篇综述强调了功能分子合成中可持续方法的重要性，并鼓励该领域的进一步研究。