The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also generates secondary metabolites with direct microbicidal activity. At the same time, bacteria themselves have adapted to both manipulate and take advantage of macrophage-specific metabolic adaptations. Here, we summarize the current knowledge on macrophage metabolism during infection, with a particular focus on understanding the ‘arms race’ between host immune cells and bacteria during immune responses.

中文翻译：

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细菌感染过程中巨噬细胞代谢的进化拉锯战


巨噬细胞的功能和表型与病原体检测密切相关。在感知病原体来源的信号和分子时，巨噬细胞会经历精心策划的极化过程，以获得病原体清除特性。这种表型变化必须得到代谢重编程的充分支持，目前已知代谢重编程支持效应功能的获得，但也产生具有直接杀菌活性的次级代谢产物。与此同时，细菌本身已经适应了操纵和利用巨噬细胞特异性的代谢适应。在这里，我们总结了目前关于感染期间巨噬细胞代谢的知识，特别关注了解免疫反应期间宿主免疫细胞和细菌之间的“军备竞赛”。