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New route to 1,4-oxazepane and 1,4-diazepane derivatives: synthesis from N-propargylamines
RSC Advances ( IF 3.9 ) Pub Date : 2016-10-11 00:00:00 , DOI: 10.1039/c6ra20718a Esmail Vessally 1, 2, 3, 4 , Akram Hosseinian 3, 4, 5, 6, 7 , Ladan Edjlali 1, 4, 8, 9, 10 , Ahmadreza Bekhradnia 4, 11, 12, 13, 14 , Mehdi D. Esrafili 4, 15, 16, 17
RSC Advances ( IF 3.9 ) Pub Date : 2016-10-11 00:00:00 , DOI: 10.1039/c6ra20718a Esmail Vessally 1, 2, 3, 4 , Akram Hosseinian 3, 4, 5, 6, 7 , Ladan Edjlali 1, 4, 8, 9, 10 , Ahmadreza Bekhradnia 4, 11, 12, 13, 14 , Mehdi D. Esrafili 4, 15, 16, 17
Affiliation
N-Propargylamines are one of the most useful and versatile building blocks in organic synthesis that are successfully transformed into many significant N-heterocycles. Due to high atom economy and shorter synthetic routes, the synthesis of 1,4-oxazepane and 1,4-diazepane cores from N-propargylamines have undergone an explosive growth in recent years. This review gives an overview of new developments in the synthesis of the title compounds from N-propargylamines in recent years. Mechanistic aspects of the reactions are considered and discussed in detail.
中文翻译:
1,4-恶唑烷和1,4-二氮杂苯衍生物的新途径:由N-炔丙基 胺合成
N-炔丙基胺是有机合成中最有用和用途最广泛的构建基块之一,已成功转化为许多重要的N-杂环。由于高原子经济性和较短的合成路线,近年来,由N-炔丙基胺合成1,4-氧杂庚烷和1,4-二氮杂pan核经历了爆炸性的增长。该综述概述了近年来由N-炔丙基胺合成标题化合物的新进展。考虑并详细讨论了反应的机理。
更新日期:2016-10-11
中文翻译:
1,4-恶唑烷和1,4-二氮杂苯衍生物的新途径:由N-炔丙基 胺合成
N-炔丙基胺是有机合成中最有用和用途最广泛的构建基块之一,已成功转化为许多重要的N-杂环。由于高原子经济性和较短的合成路线,近年来,由N-炔丙基胺合成1,4-氧杂庚烷和1,4-二氮杂pan核经历了爆炸性的增长。该综述概述了近年来由N-炔丙基胺合成标题化合物的新进展。考虑并详细讨论了反应的机理。