Dehydrogenative Electrochemical Synthesis of N-Aryl-3,4-Dihydroquinolin-2-ones by Iodine(III)-Mediated Coupling Reaction,Chemistry - A European Journal

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Dehydrogenative Electrochemical Synthesis of N-Aryl-3,4-Dihydroquinolin-2-ones by Iodine(III)-Mediated Coupling Reaction
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-11-29 , DOI: 10.1002/chem.202303388
Jessica C Bieniek ₁ , Boris Mashtakov ₁ , Dieter Schollmeyer ₁ , Siegfried R Waldvogel _{1,

2,

3}

Affiliation

An electrocatalytic hypervalent iodine(III)-mediated in-cell synthesis of 3,4-dihydroquinolin-2-ones by C−N coupling is established, applying catalytic amounts of reagents, inexpensive electrode materials and a simple galvanostatic set-up. With this method 23 examples in yields up to 96 % could be synthesized, exhibiting various functional groups. Furthermore, a 10-fold scale-up was performed and a reaction mechanism was proposed.

中文翻译：

碘(III)介导的偶联反应脱氢电化学合成N-芳基-3,4-二氢喹啉-2-酮

应用催化量的试剂、廉价的电极材料和简单的恒电流装置，建立了通过 CN 耦合电催化高价碘 (III) 介导的 3,4-二氢喹啉-2-酮的细胞内合成。通过这种方法，可以合成 23 个样品，收率高达 96%，具有各种官能团。此外，还进行了10倍的放大并提出了反应机理。

更新日期：2023-11-29

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