Autism spectrum disorder is a neuropsychiatric disorder characterized by persistent deficits in social communication and social interaction and restricted, repetitive patterns of behavior, interests, or activities. The symptoms invariably appear in early childhood and cause significant impairment in social, occupational, and other important functions. Various abnormalities in the genetic, neurological, and endocrine systems of patients with autism spectrum disorder have been reported as the etiology; however, no clear factor leading to the onset of the disease has been identified. Additionally, higher order cognitive dysfunctions, which are represented by a lack of theory of mind, sensorimotor disorders, and memory-related disorders (e.g., flashbacks), have been reported in recent years, but no theoretical framework has been proposed to explain these behavioral abnormalities. In this study, we extended Hebb's biopsychology theory to provide a theoretical framework that comprehensively explains the various behavioral abnormalities observed in autism spectrum disorder. Specifically, we propose that a wide range of symptoms in autism spectrum disorder may be caused by the formation of a rigid-autonomous phase sequence (RAPS) in the brain. Using the RAPS formation theory, we propose a biopsychological mechanism that could be a target for the treatment of autism spectrum disorders.

中文翻译：

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通过扩展赫布理论来理解自闭症谱系障碍中的感觉运动障碍：刚性自主相序的形成。

自闭症谱系障碍是一种神经精神疾病，其特征是社交沟通和社交互动持续缺陷，以及行为、兴趣或活动模式受限、重复。这些症状总是出现在儿童早期，并导致社交、职业和其他重要功能的严重损害。据报道，自闭症谱系障碍患者的遗传、神经和内分泌系统的各种异常是其病因；然而，尚未确定导致该疾病发病的明确因素。此外，近年来还报道了以缺乏心智理论、感觉运动障碍和记忆相关障碍（例如闪回）为代表的高阶认知功能障碍，但尚未提出理论框架来解释这些行为异常。在这项研究中，我们扩展了赫布的生物心理学理论，提供了一个理论框架，全面解释在自闭症谱系障碍中观察到的各种行为异常。具体来说，我们提出自闭症谱系障碍的多种症状可能是由大脑中刚性自主相序（RAPS）的形成引起的。利用 RAPS 形成理论，我们提出了一种生物心理学机制，可以作为治疗自闭症谱系障碍的目标。