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Peptide TK-HR from the Skin of Chinese Folk Medicine Frog Hoplobatrachus Rugulosus Accelerates Wound Healing via the Activation of the Neurokinin-1 Receptor
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2023-11-28 , DOI: 10.1021/acs.jmedchem.3c01434 Jiena Wu 1 , Weichen Xiong 1 , Jinqiao Li 1 , Hang Liao 1 , Jinwei Chai 1 , Xiaowen Huang 2 , Shian Lai 3 , Sergey Kozlov 4 , Xinwei Chu 5 , Xueqing Xu 1
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2023-11-28 , DOI: 10.1021/acs.jmedchem.3c01434 Jiena Wu 1 , Weichen Xiong 1 , Jinqiao Li 1 , Hang Liao 1 , Jinwei Chai 1 , Xiaowen Huang 2 , Shian Lai 3 , Sergey Kozlov 4 , Xinwei Chu 5 , Xueqing Xu 1
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Wound healing is a complex process and remains a considerable challenge in clinical trials due to the lack of ideal therapeutic drugs. Here, a new peptide TK-HR identified from the skin of the frog Hoplobatrachus rugulosus was tested for its ability to heal cutaneous wounds in mice. Topical application of TK-HR at doses of 50–200 μg/mL significantly accelerated wound closure without causing any adverse effects in the animals. In vitro and in vivo investigations proved the regulatory role of the peptide on neutrophils, macrophages, keratinocytes, and vein endothelial cells involved in the inflammatory, proliferative, and remodeling phases of wound healing. Notably, TK-HR activated the MAPK and TGF-β-Smad signaling pathways by acting on NK1R in RAW264.7 cells and mice. The current work has identified that TK-HR is a potent wound healing regulator that can be applied for the treatment of wounds, including diabetic foot ulcers and infected wounds, in the future.
中文翻译：
来自中药青蛙皮肤的肽 TK-HR 通过激活 Neurokinin-1 受体加速伤口愈合
伤口愈合是一个复杂的过程，由于缺乏理想的治疗药物，在临床试验中仍然面临着相当大的挑战。在这里，从青蛙Hoplobatrachus rugulosus的皮肤中鉴定出一种新的肽 TK-HR，并对其治愈小鼠皮肤伤口的能力进行了测试。局部应用 50-200 μg/mL 剂量的 TK-HR 可显着加速伤口闭合，且不会对动物造成任何不良影响。体外和体内研究证明了该肽对参与伤口愈合的炎症、增殖和重塑阶段的中性粒细胞、巨噬细胞、角质形成细胞和静脉内皮细胞的调节作用。值得注意的是，TK-HR 通过作用于 RAW264.7 细胞和小鼠中的 NK1R 来激活 MAPK 和 TGF-β-Smad 信号通路。目前的工作已确定TK-HR是一种有效的伤口愈合调节剂，未来可用于治疗伤口，包括糖尿病足溃疡和感染伤口。
更新日期：2023-11-28
中文翻译：
来自中药青蛙皮肤的肽 TK-HR 通过激活 Neurokinin-1 受体加速伤口愈合
伤口愈合是一个复杂的过程，由于缺乏理想的治疗药物，在临床试验中仍然面临着相当大的挑战。在这里，从青蛙Hoplobatrachus rugulosus的皮肤中鉴定出一种新的肽 TK-HR，并对其治愈小鼠皮肤伤口的能力进行了测试。局部应用 50-200 μg/mL 剂量的 TK-HR 可显着加速伤口闭合，且不会对动物造成任何不良影响。体外和体内研究证明了该肽对参与伤口愈合的炎症、增殖和重塑阶段的中性粒细胞、巨噬细胞、角质形成细胞和静脉内皮细胞的调节作用。值得注意的是，TK-HR 通过作用于 RAW264.7 细胞和小鼠中的 NK1R 来激活 MAPK 和 TGF-β-Smad 信号通路。目前的工作已确定TK-HR是一种有效的伤口愈合调节剂，未来可用于治疗伤口，包括糖尿病足溃疡和感染伤口。
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