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Various Synthetic Methods and Diverse Therapeutic Potential of Substituted Thiazine Derivatives
Current Organic Chemistry ( IF 1.7 ) Pub Date : 2023-11-27 , DOI: 10.2174/0113852728260166231101070430
Mohammad Asif 1 , Mamdouh Allahyani 2 , Ahad Amer Alsaiari 2 , Mazen Almehmadi 2
Affiliation  

Heterocyclic compounds are currently of great interest in pharmaceutical research. Many natural products, including vitamins, hormones, and antibiotics, contain heterocyclic compounds, and these substances have grown in importance. Heterocyclic thiazine derivatives have numerous pharmacological actions, including anticancer, antimicrobial, antipsychotic, anti-mycobacterial, anti-fungal, antiviral, antimycobacterial, antioxidant, analgesic, antipyretic, anti-inflammatory activities, which is present in numerous substances. The N-CS linkage in its scaffold and the ease and economy of its synthesis methods have been key factors in the development of these molecules. Recently, numerous studies considering the various biological actions of thiazines have been published. Thiazine, a six-membered heterocyclic compound with nitrogen and sulfur in its ring system, has a wide range of chemical possibilities, which has encouraged insistent research into their various synthesis processes. The current review focuses on thiazine derivatives with potential biological activities.

中文翻译:


取代噻嗪衍生物的多种合成方法和多种治疗潜力



杂环化合物目前在药物研究中引起了极大的兴趣。许多天然产物,包括维生素、激素和抗生素,都含有杂环化合物,这些物质的重要性日益增加。杂环噻嗪衍生物具有多种药理作用,包括抗癌、抗菌、抗精神病、抗分枝杆菌、抗真菌、抗病毒、抗分枝杆菌、抗氧化、镇痛、解热、抗炎活性,存在于多种物质中。其支架中的 N-CS 连接及其合成方法的简便性和经济性是这些分子开发的关键因素。最近,发表了许多考虑噻嗪类各种生物作用的研究。噻嗪是一种环系中含有氮和硫的六元杂环化合物,具有广泛的化学可能性,这鼓励了对其各种合成过程的持续研究。目前的综述重点关注具有潜在生物活性的噻嗪衍生物。
更新日期:2023-11-27
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