Quaternarized cationic poly[(vinyl chloride)-co-(vinyl chloroacetate)] binary copolymer as non-migration antibacterial additive in PVC matrix,Journal of Applied Polymer Science

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Quaternarized cationic poly[(vinyl chloride)-co-(vinyl chloroacetate)] binary copolymer as non-migration antibacterial additive in PVC matrix
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2023-11-28 , DOI: 10.1002/app.54979
Xiyan Jian ₁ , Jiaxin Sun ₁ , Xiaojing Gu ₁ , Changtong Song ₁ , Xianhong Zhang ₁ , Wantai Yang _{1,

2}

Affiliation

Antibacterial polyvinyl chloride (PVC) materials have drawn considerable attention since their wide application in medical devices. The objective of this study is to develop a novel quaternary ammonium cationic vinyl chloride copolymer, which can be potentially used as antibacterial additive in PVC matrix. Initially, the low average-number molecular weight poly[(vinyl chloride)-co-(vinyl chloroacetate)] (PVC-co-PVCA) is synthesized by precipitation copolymerization. Subsequently, quaternary ammonium cationic moieties with different lengths of alkyl chains are introduced into the copolymers via quaternization reaction between alkyl-dimethyl tertiary amines with acyl chloride groups. The successful synthesis of PVC-co-PVCA and quaternarized copolymers are carefully confirmed by Fourier transform infrared spectroscopy, nuclear magnetic resonance (1H NMR), and x-ray photoelectron spectroscopy. The antibacterial behaviors of the quaternarized copolymers and its blends with PVC are investigated. The results reveal that all the PVC blends containing at least 5% by weight of quaternarized copolymer have superior bacteriostasis ratio (>99.6%) against both Escherichia coli (E.coli) and Staphylococcus aureus (S. aureus) due to the incorporation of quaternary ammonium groups. Meanwhile, the cationic copolymer exhibits excellent antifouling and much lower migration rate (<0.4%). These interesting consequences endow the quaternarized copolymers as alternative antibacterial agents possess a great deal of potential for use in PVC materials.

中文翻译：

季铵化阳离子聚[(氯乙烯)-共-(氯乙酸乙烯酯)]二元共聚物作为PVC基体中的非迁移抗菌添加剂

抗菌聚氯乙烯（PVC）材料自从在医疗器械中广泛应用以来，引起了人们的广泛关注。本研究的目的是开发一种新型季铵阳离子氯乙烯共聚物，可用作 PVC 基质中的抗菌添加剂。首先，通过沉淀共聚合成低平均数分子量聚[(氯乙烯)-co- (氯乙酸乙烯酯)](PVC- co -PVCA)。随后，通过带有酰氯基团的烷基二甲基叔胺之间的季铵化反应，将具有不同烷基链长度的季铵阳离子部分引入到共聚物中。PVC- co -PVCA 和季铵化共聚物的成功合成通过傅里叶变换红外光谱、核磁共振 (1H NMR) 和 X 射线光电子能谱仔细证实。研究了季铵化共聚物及其与 PVC 共混物的抗菌性能。结果表明，所有含有至少 5%（重量）季铵化共聚物的 PVC 共混物由于加入了季铵盐，对大肠杆菌( E.coli ) 和金黄色葡萄球菌( S. aureus ) 均具有优异的抑菌率 (>99.6%)。铵基团。同时，阳离子共聚物表现出优异的防污性和更低的迁移率（<0.4%）。这些有趣的结果使得季铵化共聚物作为替代抗菌剂在 PVC 材料中具有巨大的应用潜力。

更新日期：2023-11-28

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