Gandouling alleviates nerve injury through PI3K/Akt/FoxO1 and Sirt1/FoxO1 signaling pathway to inhibit autophagy in the rats model of Wilson's disease,Brain and Behavior

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Gandouling alleviates nerve injury through PI3K/Akt/FoxO1 and Sirt1/FoxO1 signaling pathway to inhibit autophagy in the rats model of Wilson's disease
Brain and Behavior ( IF 2.6 ) Pub Date : 2023-11-27 , DOI: 10.1002/brb3.3325
Li Chen ₁ , Wangyang Xu ₂ , Yuting Zhang ₁ , Hao Chen ₁ , Yanquan Han ₁

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Previous studies have shown that Gandouling (GDL) may alleviate the nerve damage caused by Wilson's disease (WD) by inhibiting the autophagy of nerve cell mitochondria. However, its mechanisms are still unclear. Revealing the therapeutic mechanism of GDL is beneficial for its clinical application and provides theoretical support for the development of new formulations for treating WD.

中文翻译：

肝豆灵通过PI3K/Akt/FoxO1和Sirt1/FoxO1信号通路抑制威尔逊病大鼠模型自噬减轻神经损伤

此前的研究表明，甘豆灵（GDL）可能通过抑制神经细胞线粒体的自噬来减轻威尔逊病（WD）引起的神经损伤。然而，其机制仍不清楚。揭示GDL的治疗机制有利于其临床应用，并为开发治疗WD的新剂型提供理论支持。

更新日期：2023-11-27

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