<br>具有共价锚定聚吡咯的壳聚糖/二醛纤维素水凝胶：新型导电、抗菌、抗氧化、免疫调节和抗炎材料,Carbohydrate Polymers

当前位置： X-MOL 学术 › Carbohydr. Polym. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

具有共价锚定聚吡咯的壳聚糖/二醛纤维素水凝胶：新型导电、抗菌、抗氧化、免疫调节和抗炎材料
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2023-11-28 , DOI: 10.1016/j.carbpol.2023.121640
Simona Káčerová ₁ , Monika Muchová ₁ , Hana Doudová ₁ , Lukáš Münster ₁ , Barbora Hanulíková ₁ , Kristýna Valášková ₁ , Věra Kašpárková ₂ , Ivo Kuřitka ₃ , Petr Humpolíček ₂ , Zdenka Víchová ₁ , Ondřej Vašíček ₄ , Jan Vícha ₁

Affiliation

在这项工作中，制备了具有共价连接的聚吡咯（PPy）纳米颗粒的导电复合水凝胶。水凝胶基于部分再乙酰化壳聚糖，可在生理 pH 值下溶解，无需任何人工结构修饰或酸性环境，从而简化了合成和纯化。低毒且可持续的二醛纤维素（DAC）用于 PPy 胶体颗粒的壳聚糖交联和共价锚定。DAC 和 PPy 之间的缩合反应首次被报道，它不仅改善了 PPy 颗粒的锚定，还改善了对最终复合材料性能的控制。可溶性壳聚糖和 PPy 颗粒被证明具有协同作用，从而改善了材料的生物特性。制备的复合水凝胶无细胞毒性、无刺激性、抗菌性，能捕获常与过度炎症有关的活性氧，具有与人体组织相似的导电性，增强体外细胞生长（迁移测定），并具有与刺激中性粒细胞和巨噬细胞相关的免疫调节作用。PPy 的共价连接也加强了水凝胶网络。因此，羟醛缩合作为 PPy 共价锚定的一种方法为未来先进生物材料的发展提供了有趣的可能性。

"点击查看英文标题和摘要"

Chitosan/dialdehyde cellulose hydrogels with covalently anchored polypyrrole: Novel conductive, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory materials

In this work, conductive composite hydrogels with covalently attached polypyrrole (PPy) nanoparticles are prepared. Hydrogels are based on partially re-acetylated chitosan soluble at physiological pH without any artificial structural modifications or need for an acidic environment, which simplifies synthesis and purification. Low-toxic and sustainable dialdehyde cellulose (DAC) was used for crosslinking chitosan and covalent anchoring of PPy colloidal particles. The condensation reaction between DAC and PPy is reported for the first time and improves not only the anchoring of PPy particles but also control over the properties of the final composite. The soluble chitosan and PPy particles are shown to act in synergy, which improves the biological properties of the materials. Prepared composite hydrogels are non-cytotoxic, non-irritating, antibacterial, can capture reactive oxygen species often related to excessive inflammation, have conductivity similar to human tissues, enhance in vitro cell growth (migration assay), and have immunomodulatory effects related to the stimulation of neutrophils and macrophages. The covalent attachment of PPy also strengthens the hydrogel network. The aldol condensation as a method for PPy covalent anchoring thus presents an interesting possibility for the development of advanced biomaterials in the future.

更新日期：2023-11-28

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南