Piezoelectric Polarization Enhanced Photogenerated Carrier Separation of Bi2S3–BaTiO3 Nanostructure-Based Photoelectric Poly-L-lactic Acid Scaffold for Stimulating Cell Growth,ACS Applied Nano Materials

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Piezoelectric Polarization Enhanced Photogenerated Carrier Separation of Bi2S3–BaTiO3 Nanostructure-Based Photoelectric Poly-L-lactic Acid Scaffold for Stimulating Cell Growth
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-11-27 , DOI: 10.1021/acsanm.3c04178
Cijun Shuai _{1,

2,

3} , Xiuwen Gao ₁ , Yifeng Wang ₄ , Hongyi Qian ₄ , Wei Li ₅ , Shuling Liu ₆ , Huarui Zhou ₇ , Shuping Peng _{8,

9} , Fangwei Qi ₂

Affiliation

State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China
Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China
College of Mechanical Engineering, Xinjiang University, Urumqi 830017, China
Shenzhen Shaanxi Coal Hi-Tech Research Institute Co., Ltd, Shenzhen 518107, China
School of Science, Nanchang Institute of Technology, Nanchang 330099, China
Jiangxi Institute of Science and Technology Information, Nanchang 330013, China
Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, China
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China

Bismuth sulfide (Bi₂S₃) could respond to near-infrared light to generate photocurrent, demonstrating tremendous potential in constructing self-powered electrical stimulation to accelerate bone regeneration. Nevertheless, the facile recombination of electron–hole pairs undermined its photoelectric performance. Herein, a sea-buckthorn-like nanostructured Bi₂S₃–BaTiO₃ was synthesized by loading BaTiO₃ nanoparticles onto Bi₂S₃ nanorods through a self-assembly method and then integrated into poly-L-lactic acid (PLLA) powders to fabricate PLLA/Bi₂S₃–BaTiO₃ scaffolds. Piezoelectric BaTiO₃ would deform under stress to produce instantaneous polarization, which triggered positive and negative charges presented on the relative surfaces of BaTiO₃. Thus, the photogenerated electrons and holes of Bi₂S₃ would be, respectively, transferred to the positive and negative charged surfaces of BaTiO₃, thereby achieving the electron–hole separation. Results revealed that under ultrasonic irradiation, the photoluminescence peak intensity of Bi₂S₃–BaTiO₃ was significantly reduced compared with that of Bi₂S₃, confirming the improved electron–hole pair separation. Accordingly, the photocurrent of Bi₂S₃–BaTiO₃ was increased by approximately 1.4 times in comparison with that of Bi₂S₃. The enhanced photocurrent effectively promoted cell proliferation and differentiation by upregulating alkaline phosphatase expression, enhancing calcium nodule deposition, and promoting cellular Ca²⁺ influx. Consequently, this work provided a perspective for establishing a self-powered electrical stimulated scaffold for bone repair.

中文翻译：

基于 Bi2S3-BaTiO3 纳米结构的光电聚 L-乳酸支架的压电极化增强光生载流子分离刺激细胞生长

硫化铋（Bi ₂ S ₃）可以响应近红外光产生光电流，在构建自供电电刺激以加速骨再生方面表现出巨大的潜力。然而，电子-空穴对的轻易复合削弱了其光电性能。本文通过自组装方法将BaTiO 3 纳米颗粒负载_到Bi 2 S 3 纳米棒上_，然后_{将其集成到聚}L-乳酸（PLLA）粉末中，合成了沙棘状纳米结构Bi ₂_{S 3}_–BaTiO 3制作PLLA/Bi ₂ S ₃ –BaTiO ₃支架。压电BaTiO _{3在应力作用下会发生变形，产生瞬时极化，从而引发BaTiO}₃相对表面上出现的正负电荷。_{这样，Bi 2} S ₃的光生电子和空穴将分别转移到BaTiO ₃的带正电和负电的表面，从而实现电子-空穴分离。结果表明，在超声波照射下，Bi ₂ S ₃ –BaTiO _{3的光致发光峰强度与Bi}₂ S ₃相比显着降低，证实了电子-空穴对分离的改善。因此，与Bi 2 S 3 相比，_{Bi 2} S ₃_-BaTiO 3_的光_电流增加了大约1.4倍。增强的光电流通过上调碱性磷酸酶表达、增强钙结节沉积、促进细胞Ca ²⁺内流，有效促进细胞增殖和分化。因此，这项工作为建立用于骨修复的自供电电刺激支架提供了前景。

更新日期：2023-11-27

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