Stereocontrolled Synthesis of α-3-Deoxy-d-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using C3-p-Tolylthio-Substituted Kdo Donors: Access to Highly Branched Kdo Oligosaccharides,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Stereocontrolled Synthesis of α-3-Deoxy-d-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using C3-p-Tolylthio-Substituted Kdo Donors: Access to Highly Branched Kdo Oligosaccharides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-28 , DOI: 10.1002/anie.202313985
Ao Sun ₁ , Zipeng Li ₁ , Yuchao Wang ₁ , Shuai Meng ₂ , Xiao Zhang ₁ , Xiangbao Meng ₁ , Shuchun Li ₁ , Zhongtang Li ₁ , Zhongjun Li ₁

Affiliation

A modified donor has been developed for the glycosylation of 3-deoxy-d-manno-2-octulosonic acid (Kdo). The high reactivity and wide substrate scope of the donor enabled the synthesis of a range of Kdo-containing glycosides with complete α-stereoselectivity without the formation of 2,3-ene by-products. Several natural oligosaccharides were synthesized by a stepwise or one-pot process, including a highly branched Kdo pentasaccharide.

中文翻译：

使用 C3-对甲苯硫基取代的 Kdo 供体立体控制合成 α-3-脱氧-d-甘露-辛-2-酮糖酸 (α-Kdo) 糖苷：获得高度支化的 Kdo 寡糖

已开发出一种用于 3-脱氧-d-甘露-2-辛糖酸 (Kdo) 糖基化的修饰供体。供体的高反应活性和广泛的底物范围使得能够合成一系列具有完全α-立体选择性的含Kdo糖苷，而不形成2,3-烯副产物。通过分步或一锅法合成了几种天然低聚糖，包括高度支化的 Kdo 五糖。

更新日期：2023-11-28

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南