PURPOSE This study aims to investigate the relationships of moderate-to-vigorous physical activity (MVPA) with all-cause and disease-specific mortality. We also investigated how the association between MVPA at leisure time (LT-MVPA) and health outcomes differs at different MVPA at work (WT-MVPA) levels. METHODS The 81,601 community-dwelling Japanese persons aged 50-79 years who responded to a questionnaire in 2000-2003 were followed until 2018. Cox proportional hazard model was used to examine the association of total MVPA with risks of all-cause, cancer, heart disease, stroke and respiratory disease mortality. Then, we compared the mortality risk according to the tertile of LT-MVPA, stratified by the tertile of WT-MVPA. RESULTS During the 15.1 years of average follow-up, 16,951 deaths were identified. Even total MVPA below the recommended volume (i.e., 0.1-1.49 METs-h/day) was associated with 11% to 24% reductions in all-cause (hazard ratio [HR]: 0.89, 95% confidence interval [CI]: 0.82-0.96) and heart disease mortality (HR:0.76, CI: 0.61-0.94), compared to no MVPA at all. The further reduced risks were seen in MVPA up to 10 METs-h/day. The inverse association between LT-MVPA and mortality risks was more evident at lower WT-MVPA, which WT-MVPA was also inversely associated with the risks. CONCLUSIONS Health benefits were observed at low levels of MVPA and up to 10 METs-h/day although the fine threshold for excessive MVPA was not clear. LT-MVPA had distinct health benefits especially for persons with lower WT-MVPA.

中文翻译：

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总体和特定领域的中度至剧烈体力活动与全因和疾病特异性死亡率的关系。

目的 本研究旨在调查中度至剧烈体力活动 (MVPA) 与全因死亡率和疾病特异性死亡率的关系。我们还研究了不同工作 MVPA (WT-MVPA) 水平下休闲时间 MVPA (LT-MVPA) 与健康结果之间的关联有何不同。方法 对 2000-2003 年回答问卷的 81,601 名 50-79 岁的日本社区居民进行跟踪调查直至 2018 年。使用 Cox 比例风险模型检验总 MVPA 与全因、癌症、心脏病风险的关系。疾病、中风和呼吸系统疾病死亡率。然后，我们根据 LT-MVPA 三分位数比较死亡风险，并按 WT-MVPA 三分位数分层。结果 在平均 15.1 年的随访期间，确定了 16,951 例死亡。即使总 MVPA 低于推荐量（即 0.1-1.49 METs-h/天），全因风险降低 11% 至 24%（风险比 [HR]：0.89，95% 置信区间 [CI]：0.82与完全没有 MVPA 相比，死亡率（HR：0.76，CI：0.61-0.94）和心脏病死亡率（-0.96）。MVPA 的风险进一步降低，最高可达 10 METs-h/天。LT-MVPA 与死亡风险之间的负相关在 WT-MVPA 较低时更为明显，而 WT-MVPA 也与风险呈负相关。结论 尽管 MVPA 过量的精细阈值尚不清楚，但在低 MVPA 水平和高达 10 METs-h/天的情况下观察到健康益处。LT-MVPA 具有明显的健康益处，特别是对于 WT-MVPA 较低的人。