具有中等 ROS 清除率和抗菌能力的超薄 WOx 纳米带可有效诱导 M2 巨噬细胞极化，用于糖尿病骨缺损修复,Advanced Functional Materials

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具有中等 ROS 清除率和抗菌能力的超薄 WOx 纳米带可有效诱导 M2 巨噬细胞极化，用于糖尿病骨缺损修复
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-11-27 , DOI: 10.1002/adfm.202306319
Jiechen Wang _{1,

2,

3} , Chenguang Zhang _{1,

2,

3,

4} , Wenshu Zhang ₅ , Wenwen Liu ₆ , Yaru Guo ₆ , Pengrui Dang ₇ , Ling Wei ₆ , Han Zhao ₆ , Xuliang Deng ₆ , Shaojun Guo ₅ , Lili Chen _{1,

2,

3}

Affiliation

由于骨免疫稳态的紊乱和暴露伤口容易受到细菌感染，糖尿病骨缺损的修复仍然是生物医学领域的重大挑战。临床上，通过去除过量的活性氧（ROS）进行免疫调节可有效促进糖尿病骨缺损的修复。然而，积极的ROS清除会破坏ROS稳态，使得ROS介导的M2巨噬细胞在糖尿病组织愈合过程中的极化变得困难。在此，报道了一种具有高氧空位的超薄缺陷氧化钨（WO _x）纳米带，可同时实现适度清除ROS和高广谱光热抗菌活性，以促进糖尿病骨缺损修复。结果表明，WO _x纳米带的中等 ROS 清除能力可以重塑代谢模式，在高葡萄糖微环境中实现 86.3% 的 M2 巨噬细胞诱导。这种高诱导效率与WO _x纳米带优异的光热抗菌能力相结合，显着减轻了C57BLKS/J（BKS）-糖尿病（BKS）中耐甲氧西林金黄色葡萄球菌（ S. aureus ）感染的炎症反应，并有效促进了骨缺损的修复-db) 小鼠。

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Ultrathin WOx Nanoribbons with Moderate ROS Clearance and Antibacterial Abilities Efficiently Induce M2 Macrophage Polarization for Diabetic Bone Defect Repair

The repair of bone defects in diabetes remains a major challenge in the field of biomedicine because of the disturbance of bone immune homeostasis and the susceptibility of exposed wounds to bacterial infection. Clinically, immunoregulation by removing excessive reactive oxygen species (ROS) effectively promotes diabetic bone defect repair. However, aggressive ROS clearance can disrupt ROS homeostasis, making ROS-mediated polarization of M2 macrophages in the process of tissue healing of diabetes be difficult. Herein, an ultrathin defective tungsten oxide (WO_x) nanoribbon with high oxygen vacancies to simultaneously achieve moderate scavenging of ROS and high broad-spectrum photothermal antibacterial activity to promote diabetic bone defect repair is reported. It is demonstrated that the moderate ROS clearance ability of WO_x nanoribbons can remodel metabolic patterns for achieving 86.3% M2 macrophage induction in a high glucose microenvironment. This high induction efficiency combined with excellent photothermal antibacterial ability of WO_x nanoribbons markedly alleviated the inflammatory reaction and efficiently facilitated the repair of bone defects infected with methicillin-resistant Staphylococcus aureus (S. aureus) in C57BLKS/J (BKS)-diabetic (BKS-db) mice.

更新日期：2023-11-27

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