Elevated plasma levels of specific antiplatelet glycoprotein autoantibodies in patients with primary Sjögren syndrome with thrombocytopenia,Clinical Rheumatology

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Elevated plasma levels of specific antiplatelet glycoprotein autoantibodies in patients with primary Sjögren syndrome with thrombocytopenia
Clinical Rheumatology ( IF 2.9 ) Pub Date : 2023-11-24 , DOI: 10.1007/s10067-023-06818-y
Yingxin Ruan ₁ , Hongchen Bi ₂ , Xiaoli Luo ₂ , Aiming Pang ₃ , Pengyu Zhang ₄ , Yujie Cui ₂

Affiliation

Introduction

Thrombocytopenia is one of the primary Sjögren’s syndrome (pSS) hematological manifestations. The objective of this study was to evaluate the possible roles of antiplatelet glycoprotein autoantibodies in the pathogenesis of thrombocytopenia in primary Sjögren’s syndrome (pSS).

Methods

The level of plasma anti-glycoprotein Ib, IIIa and IIb/IIIa autoantibodies in 36 pSS patients without thrombocytopenia and 35 pSS patients with thrombocytopenia, 36 Idiopathic thrombocytopenic purpura (ITP) patients and 39 normal control were measured with enzyme-linked immunosorbent assay (ELISA).

Results

The level of anti-GPIb, GPIIIa, GPIIb/IIIa autoantibodies (A490) in the pSS with thrombocytopenia was significantly higher than that of pSS without thrombocytopenia (0.813 ± 0.161 vs 0.688 ± 0.133; 0.917 ± 0.094 vs 0.802 ± 0.070; 0.911 ± 0.125 vs 0.782 ± 0.109). Incidences of the anti-GPIb, GPIIIa, GPIIb/IIIa autoantibodies in the pSS with thrombocytopenia was significantly higher than that of pSS without thrombocytopenia (25.7% vs 0%; 65.7% vs 11.1%; 31.4% vs 0%). In patients with pSS, there was a lower platelet count in anti-GPIb, GPIIIa, GPIIb/IIIa autoantibodies positive patients ((25.67 ± 5.5) × 10^9/L vs (116.8 ± 84.52) × 10^9/L; 29.04 ± 11.33 × 10^9/L vs (152.0 ± 75.47) × 10^9/L; (31.55 ± 14.0) × 10^9/L vs (118.8 ± 85.24) × 10^9/L).

Conclusion

Elevated plasma levels of anti-platelet glycoprotein autoantibodies may play a role in the pathogenesis of thrombocytopenia in pSS.

Key Points

• The level of anti-GPIb, GPIIIa, GPIIb/IIIa autoantibodies (A490) in the pSS with thrombocytopenia was increased.

• Incidences of the anti-GPIb, GPIIIa, GPIIb/IIIa autoantibodies in the pSS with thrombocytopenia was increased.

• In patients with pSS, there was a lower platelet count in anti-GPIb, GPIIIa, GPIIb/IIIa autoantibodies positive patients.

中文翻译：

原发性干燥综合征合并血小板减少症患者血浆特异性抗血小板糖蛋白自身抗体水平升高

介绍

血小板减少症是原发性干燥综合征 (pSS) 的血液学表现之一。本研究的目的是评估抗血小板糖蛋白自身抗体在原发性干燥综合征（pSS）血小板减少症发病机制中的可能作用。

方法

采用酶联免疫吸附法（ELISA）检测36例无血小板减少的pSS患者、35例伴血小板减少的pSS患者、36例特发性血小板减少性紫癜（ITP）患者和39例正常对照者血浆抗糖蛋白Ib、IIIa和IIb/IIIa自身抗体水平。）。

结果

伴血小板减少症的 pSS 中抗 GPIb、GPIIIa、GPIIb/IIIa 自身抗体 (A490) 水平显着高于不伴血小板减少症的 pSS（0.813 ± 0.161 vs 0.688 ± 0.133；0.917 ± 0.094 vs 0.802 ± 0.070；0.911 ± 0.125对比 0.782 ± 0.109）。伴血小板减少的 pSS 中抗 GPIb、GPIIIa、GPIIb/IIIa 自身抗体的发生率显着高于不伴血小板减少的 pSS（25.7% vs 0%；65.7% vs 11.1%；31.4% vs 0%）。在 pSS 患者中，抗 GPIb、GPIIIa、GPIIb/IIIa 自身抗体阳性患者的血小板计数较低 ((25.67 ± 5.5) × 10^9/L vs (116.8 ± 84.52) × 10^9/L；29.04 ± 11.33 × 10^9/L 与 (152.0 ± 75.47) × 10^9/L；(31.55 ± 14.0) × 10^9/L 与 (118.8 ± 85.24) × 10^9/L)。