具有优异润滑和成骨性能的仿生硬软复合支架用于治疗骨软骨缺损,Advanced Materials Interfaces

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具有优异润滑和成骨性能的仿生硬软复合支架用于治疗骨软骨缺损
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2023-11-27 , DOI: 10.1002/admi.202300473
Keming Hu _{1,

2} , Qi Ma ₁ , Weicheng Guo ₂ , Weiwei Zhao ₂ , Yanran Zhao ₂ , Xu Cai ₁ , Hongyu Zhang _{1,

2,

3}

Affiliation

天然关节软骨是一种典型的自愈和超级润滑系统，能够在生理负荷下保持极低的摩擦。软骨磨损和意外创伤可导致软骨和软骨下骨不可逆的缺陷，关节内润滑显着减少，导致严重的骨关节炎和骨软骨缺损的发展。为了解决骨软骨缺损这一重要的临床问题，设计并开发了一种仿生硬软（PEEK-润滑水凝胶）复合支架。通过紫外引发将聚乙二醇二丙烯酰胺（PEGDAA）和2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）在聚醚醚酮（PEEK）基材上聚合形成牢固的界面结合，并通过聚多巴胺涂层将纳米羟基磷灰石沉积在多孔PEEK基材上以改善成骨能力。因此，成功开发了具有润滑和成骨活性的复合支架。摩擦学测试表明，复合支架的润滑性能是基于上层水凝胶层的水化润滑机制，体外和体内实验表明，复合支架具有优异的生物相容性和生物活性。总之，制备硬软复合支架的仿生策略为治疗骨软骨缺损提供了一种有前景的方法，并为组织工程支架中功能性基于 PEEK 的生物材料的设计提供了指导。

"点击查看英文标题和摘要"

Bioinspired Hard–Soft Composite Scaffold with Excellent Lubrication and Osteogenic Properties for the Treatment of Osteochondral Defect

Natural articular cartilage is a typical self-healing and superlubrication system capable of maintaining extremely low friction under physiological loadings. Cartilage wear and accidental trauma can cause irreversible defects to cartilage and subchondral bone with a significant decrease in intra-articular lubrication, leading to the development of severe osteoarthritis and osteochondral defect. To address the important clinical problem of osteochondral defect, a bioinspired hard–soft (PEEK-lubrication hydrogel) composite scaffold is designed and developed. The polymerization of polyethylene glycol diacrylamide (PEGDAA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) on polyetheretherketone (PEEK) substrate is achieved by UV initiation to form a strong interfacial bonding, and nano-hydroxyapatite is deposited on porous PEEK substrate via polydopamine coating to improve osteogenic capability. Accordingly, the composite scaffold is successfully developed with lubrication and osteogenic activity. The tribological tests show that the lubrication performance of the composite scaffold is based on the hydration lubrication mechanism of the upper hydrogel layer, and the in vitro and in vivo experiments demonstrate that the composite scaffold is endowed with excellent biocompatibility and bioactivity. In conclusion, the bioinspired strategy for preparing a hard–soft composite scaffold shows a promising way in the treatment of osteochondral defect and provided a guideline for designing functional PEEK-based biomaterials in tissue engineering scaffolds.

更新日期：2023-11-27

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