1,2,4-Triazole benzamide derivative TPB against Gaeumannomyces graminis var. tritici as a novel dual-target fungicide inhibiting ergosterol synthesis and adenine nucleotide transferase function,Pest Management Science

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1,2,4-Triazole benzamide derivative TPB against Gaeumannomyces graminis var. tritici as a novel dual-target fungicide inhibiting ergosterol synthesis and adenine nucleotide transferase function
Pest Management Science ( IF 3.8 ) Pub Date : 2023-11-27 , DOI: 10.1002/ps.7900
Limin Wang ₁ , Xiaoyu Song ₁ , Yi-Nan Cheng _{2,

3} , Senxiang Cheng ₁ , Tong Chen ₁ , Honglian Li _{2,

3} , Jingming Yan ₂ , Xiafei Wang ₂ , Haifeng Zhou ₂

Affiliation

Isopropyl 4-(2-chloro-6-(1H-1,2,4-triazol-1-yl)benzamido)benzoate (TPB) was a 1,2,4-triazole benzoyl arylamine derivative with excellent antifungal activity, especially against Gaeumannomyces graminis var. tritici (Ggt). Its mechanism of action was investigated by transmission electron microscopy (TEM) observation, assays of sterol composition, cell membrane permeability, intracellular ATP and mitochondrial membrane potential, and mPTP permeability, ROS measurement, RNA sequencing (RNA-seq) analysis.

中文翻译：

1,2,4-三唑苯甲酰胺衍生物 TPB 抗禾本科全蚀菌变种小麦作为一种新型双靶点杀菌剂，抑制麦角甾醇合成和腺嘌呤核苷酸转移酶功能

4-(2-氯-6-(1 H -1,2,4-三唑-1-基)苯甲酰氨基)苯甲酸异丙酯(TPB)是一种1,2,4-三唑苯甲酰基芳胺衍生物，具有优异的抗真菌活性，特别是对抗全麦酵母 graminis var.小麦（ Ggt ）。通过透射电子显微镜（TEM）观察、甾醇成分测定、细胞膜通透性、细胞内ATP和线粒体膜电位、mPTP通透性、ROS测量、RNA测序（RNA-seq）分析来研究其作用机制。

更新日期：2023-11-27

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