Abstract

A series of novel [4-(2-nitrobenzyl)piperazin-1-yl](phenyl)methanone derivatives containing piperazine structures were designed and synthesized. (3,7-Dichloroquinolin-8-yl)[4-(2-nitrobenzyl)piperazin-1-yl]methanone was selected to confirm the spatial structure through X-ray diffraction. Herbicidal activity of the target compounds was evaluated against the pre-emergence of Echinochloa crusgalli L., Lolium perenne L., Amaranthus retroflexus L. and Lactuca sativa var. ramosa Hort. Herbicidal activity of compounds with different substituent on the phenyl followed an order of magnitude that was given as: donor-drawing group > neutral group > electron-drawing group on Lactuca sativa var. ramosa Hort. (2,3-Dimethylphenyl)[4-(2-nitrobenzyl)piperazin-1-yl]methanone showed stronger herbicidal activity against the pre-emergence of Echinochloa crusgalli L. and Lolium perenne, while (2-chlorophenyl)-[4-(2-nitrobenzyl)piperazin-1-yl]methanone showed stronger herbicidal activity against Amaranthus retroflexus L. and Lactuca sativa var. ramosa Hort.

中文翻译：

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[4-(2-硝基苯甲基)哌嗪-1-基](苯基)甲酮衍生物的合成及除草活性评价

摘要

设计并合成了一系列含有哌嗪结构的新型[4-(2-硝基苯甲基)哌嗪-1-基](苯基)甲酮衍生物。选择(3,7-二氯喹啉-8-基)[4-(2-硝基苯甲基)哌嗪-1-基]甲酮通过X射线衍射确认空间结构。目标化合物的除草活性针对稗草、黑麦草、反枝苋和莴苣的出苗前进行了评估。拉莫萨霍特。苯基上不同取代基的化合物对莴苣的除草活性大小顺序为：供体基团>中性基团>吸电子基团。拉莫萨霍特。(2,3-二甲基苯基)[4-(2-硝基苯甲基)哌嗪-1-基]甲酮对稗草和多年生黑麦草的出苗前除草活性较强，而(2-氯苯基)-[4- (2-硝基苄基)哌嗪-1-基]甲酮对反枝苋和莴苣有较强的除草活性。拉莫萨霍特。