Toxicity of the emerging mycotoxins beauvericin and enniatins: A mini-review,Toxicon

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Toxicity of the emerging mycotoxins beauvericin and enniatins: A mini-review
Toxicon ( IF 2.6 ) Pub Date : 2023-11-25 , DOI: 10.1016/j.toxicon.2023.107534
Amanda Lopes Hasuda ₁ , Ana Paula F R L Bracarense ₁

Affiliation

Beauvericin and enniatins, emerging mycotoxins produced mainly by species, are natural contaminants of cereals and cereal products. These mycotoxins are cyclic hexadepsipeptides with ionophore properties and their toxicity mechanism is related to their ability to transport cations across the cell membrane. Beauvericin and enniatins are cytotoxic, as they decrease cell viability, promote cell cycle arrest, and increase apoptosis and the generation of reactive oxygen species in several cell lines. They also cause changes at the transcriptomic level and have immunomodulatory effects and . Toxicokinetic results are scarce, and, despite its proven toxic effects , no regulation or risk assessment has yet been performed due to a lack of data. This mini-review aims to report the information available in the literature on studies of and toxic effects with beauvericin and enniatins, which are mycotoxins of increasing interest to animal and human health.

中文翻译：

新出现的霉菌毒素白僵菌素和恩尼汀的毒性：小综述

白僵菌素和恩尼亚汀是主要由物种产生的新兴霉菌毒素，是谷物和谷物产品的天然污染物。这些霉菌毒素是具有离子载体特性的环状己缩酚肽，其毒性机制与其跨细胞膜运输阳离子的能力有关。白僵菌素和恩尼汀具有细胞毒性，因为它们会降低细胞活力，促进细胞周期停滞，并增加多种细胞系中的细胞凋亡和活性氧的产生。它们还会引起转录组水平的变化并具有免疫调节作用。毒代动力学结果很少，尽管已证明其毒性作用，但由于缺乏数据，尚未进行监管或风险评估。这篇小型综述旨在报告文献中有关白僵菌素和恩尼汀的研究及其毒性作用的信息，这两种霉菌毒素对动物和人类健康的影响越来越大。

更新日期：2023-11-25

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