一步合成 MXene 功能化 PEDOT:PSS 导电聚合物水凝胶，用于可穿戴和无创监测汗液葡萄糖,Sensors and Actuators B: Chemical

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一步合成 MXene 功能化 PEDOT:PSS 导电聚合物水凝胶，用于可穿戴和无创监测汗液葡萄糖
Sensors and Actuators B: Chemical ( IF 8.0 ) Pub Date : 2023-11-25 , DOI: 10.1016/j.snb.2023.135055
Yawen Pan , Meiru He , Jing Wu , Hongbin Qi , Yuanyuan Cheng

可穿戴生物传感器因其通过对生物体液中的生化标记物进行无创和动态监测来提供实时和连续的生理信息的能力而受到广泛关注。特别是，可穿戴和柔性电化学传感器已广泛用于以可量化和非侵入性的方式检测人体汗液中的生物标志物。在此，我们提出了一种新型 MXene 功能化 PEDOT:PSS 导电复合水凝胶电化学生物传感器，用于连续无创监测人体血糖。在整个制备过程中，水凝胶中添加了乙二醇（EG），有助于聚合物链的扩展，产生优异的导电性和多孔网络，有助于提高材料的成膜性能、柔韧性和稳定性，还改善了粉状物料的堆积和剥离问题。水凝胶生物传感器检测葡萄糖的极限低至1.9 μM，灵敏度为21.7 μA⋅mM⋅cm。此外，将带有丝网印刷碳电极（SPCE）的水凝胶用作体外皮肤贴片，用于人体连续无创汗液葡萄糖监测。生物传感器的结果显示与血糖仪读数具有良好的相关性。我们相信，这种葡萄糖生物传感器为糖尿病患者血糖的无创可穿戴监测奠定了基础。

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One-step synthesis of MXene-functionalized PEDOT:PSS conductive polymer hydrogels for wearable and noninvasive monitoring of sweat glucose

Wearable biosensors have gained substantial attention for their capacity to deliver real-time and continuous physiological information through noninvasive and dynamic monitoring of biochemical markers in biological fluids. In particular, wearable and flexible electrochemical sensors have found extensive usage for the detection of biomarkers in human sweat in a quantifiable and noninvasive manner. Herein, we present a novel MXene-functionalized PEDOT:PSS conducting composite hydrogels-based electrochemical biosensor for continuous noninvasive monitoring of human glucose. Ethylene glycol (EG) was added to the hydrogel throughout the preparation process, aiding in the expansion of the polymer chains and resulting in excellent electrical conductivity and porous networks, which helps to increase the film-forming properties, flexibility and stability of the material, and also improves the stacking and peeling problems of powdered materials. The limit of the hydrogel biosensor for glucose detection was as low as 1.9 μM and the sensitivity was 21.7 μA⋅mM⋅cm. Furthermore, the hydrogel incorporated with screen-printed carbon electrodes (SPCE) was employed to the human body for continuous noninvasive sweat glucose monitoring as the skin patch in vitro. The results of the biosensor showed good correlation with glucose meter readings. We believe that this glucose biosensor lays the foundation for noninvasive wearable monitoring of glucose in diabetic patients.

更新日期：2023-11-25

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