Imidazo[2,1-b]oxazole and 2,3-dihydroimidazo[2,1-b]oxazole ring systems are commonly employed in therapeutically active molecules. In this article, the authors review the utilization of these core scaffolds as chemotherapeutic agents from 2018 to 2022. These scaffolds possess many important biological activities including antimicrobial and anticancer, among others. This review covers their biological activities and structure-activity relationships. One of the most important drugs in this class of compounds is the antitubercular agent delamanid. In this paper, the compounds structure-activity relationship and preclinical and clinical trial data are thoroughly presented.

中文翻译：

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2,3-二氢咪唑并[2,1-b]恶唑和咪唑并[2,1-b]恶唑衍生物作为化疗药物的评价。

咪唑并[2,1-b]恶唑和2,3-二氢咪唑并[2,1-b]恶唑环系统通常用于治疗活性分子。在本文中，作者回顾了 2018 年至 2022 年这些核心支架作为化疗药物的利用情况。这些支架具有许多重要的生物活性，包括抗菌和抗癌等。本综述涵盖了它们的生物活性和构效关系。这类化合物中最重要的药物之一是抗结核药德拉马尼。本文全面介绍了化合物的构效关系以及临床前和临床试验数据。