Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis,Autonomic Neuroscience

当前位置： X-MOL 学术 › Auton. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis
Autonomic Neuroscience ( IF 3.2 ) Pub Date : 2023-11-23 , DOI: 10.1016/j.autneu.2023.103132
Shin Jie Yong ₁ , Alice Halim ₂ , Shiliang Liu ₃ , Michael Halim ₄ , Ahmad A Alshehri ₅ , Mohammed A Alshahrani ₅ , Mohammed M Alshahrani ₅ , Amal H Alfaraj ₆ , Lamees M Alburaiky ₇ , Faryal Khamis ₈ , Muzaheed ₉ , Bashayer M AlShehail ₁₀ , Mubarak Alfaresi ₁₁ , Reyouf Al Azmi ₁₂ , Hawra Albayat ₁₃ , Nawal A Al Kaabi ₁₄ , Mashael Alhajri ₁₅ , Kawthar Amur Salim Al Amri ₁₆ , Jameela Alsalman ₁₇ , Sarah A Algosaibi ₁₈ , Mona A Al Fares ₁₉ , Taghreed N Almanaa ₂₀ , Yahya A Almutawif ₂₁ , Ranjan K Mohapatra ₂₂ , Ali A Rabaan ₂₃

Affiliation

Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia.
Shanghai Medical College, Fudan University, Shanghai, China.
Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ontario, Canada.
Department of Biomedical Science, School of Science, Engineering and Environment, University of Salford, Greater Manchester, United Kingdom.
Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia.
Pediatric Department, Abqaiq General Hospital, First Eastern Health Cluster, Abqaiq, Saudi Arabia.
Pediatric Department, Safwa General Hospital, Eastern Health Cluster, Safwa, Saudi Arabia.
Infection Diseases unit, Department of Internal Medicine, The Royal Hospital, Muscat, Oman.
Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Pharmacy Practice Department, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Pathology and Laboratory Medicine, Zayed Military Hospital, Abu Dhabi, United Arab Emirates; Department of Pathology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Infection Prevention and Control, Eastern Health Cluster, Dammam, Saudi Arabia.
Infectious Disease Department, King Saud Medical City, Riyadh, Saudi Arabia.
Sheikh Khalifa Medical City, Abu Dhabi Health Services Company, Abu Dhabi, United Arab Emirates; College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates.
Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Infection and Control Department, Armed Forces Hospital, Azaibah, Oman.
Infection Disease Unit, Department of Internal Medicine, Salmaniya Medical Complex, Ministry of Health, Manama, Bahrain.
Academic and Clinical Training, Eastern Health Cluster, Rural Health Network, Dammam, Saudi Arabia.
Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Department of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
Department of Chemistry, Government College of Engineering, Keonjhar, India.
Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Public Health and Nutrition, The University of Haripur, Haripur, Pakistan.

Purpose

To address recent concerns of postural orthostatic tachycardia syndrome (POTS) occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination.

Methods

We searched PubMed, Web of Science, and Scopus as of 1st June 2023. We performed a systematic review and meta-analysis of pooled POTS rate in SARS-CoV-2-infected and COVID-19-vaccinated groups from epidemiological studies, followed by subgroup analyses by characteristic. Meta-analysis of risk ratio was conducted to compare POTS rate in infected versus uninfected groups. Meta-analysis of demographics was also performed to compare cases of post-infection and post-vaccination POTS from case reports and series.

Results

We estimated the pooled POTS rate of 107.75 (95 % CI: 9.73 to 273.52) and 3.94 (95 % CI: 0 to 16.39) cases per 10,000 (i.e., 1.08 % and 0.039 %) in infected and vaccinated individuals based on 5 and 2 studies, respectively. Meta-regression revealed age as a significant variable influencing 86.2 % variance of the pooled POTS rate in infected population (P < 0.05). Moreover, POTS was 2.12-fold more likely to occur in infected than uninfected individuals (RR = 2.12, 95 % CI: 1.71 to 2.62, P < 0.001). Meta-analyzed demographics for cases of post-infection (n = 43) and post-vaccination (n = 17) POTS found no significant differences in several variables between groups, except that the time from exposure to symptom onset was shorter for cases of post-vaccination POTS (P < 0.05).

Conclusion

Although evidence is limited for post-vaccination POTS, our study showed that POTS occur more frequently following SARS-CoV-2 infection than COVID-19 vaccination.

中文翻译：

SARS-CoV-2 感染与 COVID-19 疫苗接种后 POTS 的汇总率和人口统计数据：系统评价和荟萃分析

目的

解决最近对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染和 2019 冠状病毒病 (COVID-19) 疫苗接种后发生的体位性心动过速综合征 (POTS) 的担忧。

方法

我们检索了截至 2023 年 6 月 1 日的 PubMed、Web of Science 和 Scopus。我们对流行病学研究中 SARS-CoV-2 感染者和 COVID-19 疫苗接种组的 POTS 率进行了系统回顾和荟萃分析，随后按特征进行亚组分析。对风险比进行荟萃分析，比较感染组与未感染组的 POTS 率。还进行了人口统计学荟萃分析，以比较病例报告和系列中感染后和疫苗接种后的 POTS 病例。

结果

我们根据 5 和 2 估计，感染者和接种疫苗个体中的汇总 POTS 率为 107.75 例（95% CI：9.73 至 273.52）和 3.94 例（95% CI：0 至 16.39）例/10,000 例（即 1.08% 和 0.039%）。分别研究。荟萃回归显示，年龄是影响感染人群中汇总 POTS 率 86.2% 方差的显着变量（ P < 0.05）。此外，感染者发生 POTS 的可能性是未感染者的 2.12 倍（RR = 2.12，95% CI：1.71 至 2.62， P < 0.001）。对感染后 ( n = 43) 和疫苗接种后 ( n = 17) 病例的人口统计学荟萃分析发现，组间的几个变量没有显着差异，只是感染后病例从暴露到症状出现的时间较短。 - 疫苗接种 POTS ( P < 0.05)。