Carbohydrate Research ( IF 2.4 ) Pub Date : 2023-11-23 , DOI: 10.1016/j.carres.2023.108987 Shanshan Wei 1 , Chen Chen 2 , Jiaying Lai 1 , Yanjiang Zhang 2 , Xinmiao Nong 2 , Fangfang Duan 2 , Ping Wu 2 , Sasa Wang 3 , Haibo Tan 4
Three previously undescribed isopimarane-type diterpene glycosides named as xylarcurcosides A-C (1–3) along with two known ones 16-α-d-mannopyranosyloxyisopimar-7-en-19-oic acid (4) and hypoxylonoid A (5) were successfully isolated from an ethyl acetate extract of the endophytic fungus Xylaria curta YSJ-5 growing in leaves of Alpinia zerumbet. The spectroscopic methods, electronic circular dichroism (ECD) calculations, and X-ray diffraction experiments were conducted to identify their absolute chemical structures. All these compounds were tested for in vitro cytotoxic, anti-inflammatory, α-glucosidase inhibitory, and antibacterial activities. As a result, these novel compounds demonstrated no obvious cytotoxic and antibacterial activity.
中文翻译:
Xylarcurcosides AC,来自 Xylaria curta YSJ-5 的三种新型异海麻烷型二萜糖苷
成功分离出三种先前未描述的异海松烷型二萜糖苷,称为木糖苷 AC ( 1 – 3 ) 以及两种已知的 16- α - d -mannopyranosyloxyisopimar-7-en-19-oic 酸 ( 4 ) 和次木糖醇 A ( 5 )来自生长在Alpinia zerumbet叶子中的内生真菌Xylaria curta YSJ-5的乙酸乙酯提取物。通过光谱方法、电子圆二色性(ECD)计算和X射线衍射实验来鉴定其绝对化学结构。所有这些化合物均经过体外细胞毒性、抗炎、 α-葡萄糖苷酶抑制和抗菌活性测试。结果,这些新化合物没有表现出明显的细胞毒性和抗菌活性。