<br>工程设计具有高生物相容性的抗菌金属-酚醛网络纳米粒子用于伤口愈合,Advanced Materials

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工程设计具有高生物相容性的抗菌金属-酚醛网络纳米粒子用于伤口愈合
Advanced Materials ( IF 27.4 ) Pub Date : 2023-11-23 , DOI: 10.1002/adma.202307680
Rongxin Yu ₁ , Hongping Chen ₁ , Jian He ₂ , Zhichao Zhang ₃ , Jiajing Zhou ₄ , Qinqin Zheng ₁ , Zhouping Fu ₁ , Chengyin Lu ₁ , Zhixing Lin ₅ , Frank Caruso ₅ , Xiangchun Zhang ₁

Affiliation

抗生素耐药细菌会引起持续和反复的微生物感染，从而对全球健康构成威胁。为了解决这个问题，人们开发出了耐药性低但杀菌作用强的抗菌纳米颗粒（NP）。然而，许多已开发的纳米颗粒的生物安全性较差，其合成往往涉及复杂的程序，且抗菌作用模式尚不清楚。本文报道了一种简单的策略，通过在水溶液中一步组装晶种剂（二乙基二硫代氨基甲酸酯）、天然多酚和金属离子（例如 Cu ²⁺ ）来设计抗菌金属-酚网络（am-MPN）纳米颗粒。。基于 Cu ²⁺的 am-MPN NPs 显示出比大多数报道的纳米材料更低的 Cu ²⁺抗菌浓度（低 10-1000 倍），并且在各种模型（包括细胞、血液、斑马鱼和小鼠）中的毒性可以忽略不计。纳米颗粒的多种抗菌模式已被确定，包括细菌壁破坏、活性氧产生和醌蛋白形成，其中后者是基于多酚的 am-MPN 纳米颗粒抗菌活性的独特途径。该纳米粒子对多重耐药细菌（如耐甲氧西林金黄色葡萄球菌（MRSA））表现出优异的性能，有效抑制和破坏细菌生物膜，促进MRSA感染的皮肤伤口的愈合。这项研究为金属酚醛材料的抗菌性能和抗菌金属有机材料的合理设计提供了见解。

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Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety and their synthesis often involves complex procedures and the antimicrobial modes of action are unclear. Herein, a simple strategy is reported for designing antimicrobial metal‒phenolic network (am-MPN) NPs through the one-step assembly of a seeding agent (diethyldithiocarbamate), natural polyphenols, and metal ions (e.g., Cu²⁺) in aqueous solution. The Cu²⁺-based am-MPN NPs display lower Cu²⁺ antimicrobial concentrations (by 10–1000 times) lower than most reported nanomaterials and negligible toxicity across various models, including, cells, blood, zebrafish, and mice. Multiple antimicrobial modes of the NPs have been identified, including bacterial wall disruption, reactive oxygen species production, and quinoprotein formation, with the latter being a distinct pathway identified for the antimicrobial activity of the polyphenol-based am-MPN NPs. The NPs exhibit excellent performance against multidrug-resistant bacteria (e.g., methicillin-resistant Staphylococcus aureus (MRSA)), efficiently inhibit and destroy bacterial biofilms, and promote the healing of MRSA-infected skin wounds. This study provides insights on the antimicrobial properties of metal‒phenolic materials and the rational design of antimicrobial metal‒organic materials.

更新日期：2023-11-23

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