<br>内鼻海马胆囊收缩素通过促进海马 CA3-CA1 突触的神经可塑性来调节空间学习,Cell Reports

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内鼻海马胆囊收缩素通过促进海马 CA3-CA1 突触的神经可塑性来调节空间学习
Cell Reports ( IF 7.5 ) Pub Date : 2023-11-17 , DOI: 10.1016/j.celrep.2023.113467
Junfeng Su ₁ , Fengwen Huang ₂ , Yu Tian ₃ , Ran Tian ₃ , Gao Qianqian ₃ , Stephen Temitayo Bello ₂ , Dingxaun Zeng ₃ , Peter Jendrichovsky ₁ , C Geoffrey Lau ₃ , Wenjun Xiong ₄ , Daiguan Yu ₅ , Micky Tortorella ₆ , Xi Chen ₇ , Jufang He ₈

Affiliation

Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China.
Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong SAR, P.R. China.
Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China.
Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China; City University of Hong Kong Shenzhen Research Institute, Shenzhen, P.R. China.
Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, P.R. China.
Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong SAR, P.R. China; Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, P.R. China.
Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China; City University of Hong Kong Shenzhen Research Institute, Shenzhen, P.R. China.
Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China; Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P.R. China; City University of Hong Kong Shenzhen Research Institute, Shenzhen, P.R. China.

海马体广泛受到神经调节的影响。然而，神经肽如何塑造海马体的功能以及相关的空间学习和记忆仍不清楚。在这里，我们发现胆囊收缩素（CCK）在从内侧内嗅皮层（MEC）到海马的异质突触神经调节中的关键作用。 CCK 基因的系统性敲除会损害 CA3-CA1 LTP 和空间相关的表现。 MEC 提供了大部分投射到海马区的 CCK 阳性神经元，这以频率和 NMDA 受体 (NMDAR) 依赖性方式增强了 CA3-CA1 异质突触的长期可塑性。选择性抑制 MEC CCKergic 神经元或下调其 CCK mRNA 水平也会损害 CA3-CA1 LTP 形成和动物在水迷宫中的表现。这种兴奋性海马外投射在高频激励下释放 CCK，并在动物探索过程中活跃。我们的结果揭示了内嗅 CCKergic 投射在电生理和行为水平上桥接海马内和海马外回路中的关键作用。

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更新日期：2023-11-17

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