<br>ccTCM：促进中药研究的定量成分和化合物平台,Computational and Structural Biotechnology Journal

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ccTCM：促进中药研究的定量成分和化合物平台
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2023-11-20 , DOI: 10.1016/j.csbj.2023.11.030
Dongqing Yang ₁ , Zhu Zhu ₂ , Qi Yao ₂ , Cuihua Chen ₃ , Feiyan Chen ₃ , Ling Gu ₃ , Yucui Jiang ₃ , Lin Chen ₄ , Jingyuan Zhang ₅ , Juan Wu ₁ , Xingsu Gao ₁ , Junqin Wang ₁ , Guochun Li ₁ , Yunan Zhao ₂

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中医（TCM）数据库在弥合中医与现代医学之间的差距以及促进中医的普及方面发挥着至关重要的作用。阐明中药材的生物活性成分是中医现代化和新药发现的关键。然而，当前中医数据库的一个缺点是缺乏关于中药材成分的定量数据。在此，我们介绍了 ccTCM，这是一个基于 Web 的平台，旨在为医学专家提供基于成分和化合物含量的中医资源和分析服务。在设计特点方面，ccTCM 结合了资源分配、相似性分析和分子机制分析，以加速中药生物活性成分的发现。中药包含临床常用的中药材 273 种，涵盖 29 种功能分类。通过检索和比较，我们最终采用了 2043 项研究，从中收集了每种中药中含量大于 0.001 % 的化合物，共提取出 1449 种化合物。随后，我们通过集成多个数据库收集了 40,767 个化合物-靶点对。综上所述，ccTCM 是一个多功能平台，中医科学家可以使用该平台根据中药材的定量成分进行科学和临床中医研究。ccTCM 可在 http://www.cctcm.org.cn 免费获取。

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ccTCM: A quantitative component and compound platform for promoting the research of traditional Chinese medicine

Traditional Chinese medicine (TCM) databases play a vital role in bridging the gap between TCM and modern medicine, as well as in promoting the popularity of TCM. Elucidating the bioactive ingredients of Chinese medicinal materials is key to TCM modernization and new drug discovery. However, one drawback of current TCM databases is the lack of quantitative data on the constituents of Chinese medicinal materials. Herein, we present ccTCM, a web-based platform designed to provide a component and compound-content-based resource on TCM and analysis services for medical experts. In terms of design features, ccTCM combines resource distribution, similarity analysis, and molecular-mechanism analysis to accelerate the discovery of bioactive ingredients in TCM. ccTCM contains 273 Chinese medicinal materials commonly used in clinical settings, covering 29 functional classifications. By searching and comparing, we finally adopted 2043 studies, from which we collected the compounds contained in each TCM with content greater than 0.001 %, and a total of 1449 were extracted. Subsequently, we collected 40,767 compound-target pairs by integrating multiple databases. Taken together, ccTCM is a versatile platform that can be used by TCM scientists to perform scientific and clinical TCM studies based on quantified ingredients of Chinese medicinal materials. ccTCM is freely accessible at http://www.cctcm.org.cn.

更新日期：2023-11-20

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