5α-Tetrahydrocorticosterone: A topical anti-inflammatory glucocorticoid with an improved therapeutic index in a murine model of dermatitis,British Journal of Pharmacology

当前位置： X-MOL 学术 › Br. J. Pharmacol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

5α-Tetrahydrocorticosterone: A topical anti-inflammatory glucocorticoid with an improved therapeutic index in a murine model of dermatitis
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2023-11-21 , DOI: 10.1111/bph.16285
Dawn Elizabeth Watson Livingstone _{1,

2} , Karen Sooy ₁ , Catherine Sykes ₁ , Scott Peter Webster ₁ , Brian Robert Walker _{1,

3} , Ruth Andrew ₁

Affiliation

Glucocorticoids are powerful anti-inflammatory drugs, but are associated with many side-effects. Topical application in atopic dermatitis leads to skin thinning, metabolic changes, and adrenal suppression. 5α-Tetrahydrocorticosterone (5αTHB) is a potential selective anti-inflammatory with reduced metabolic effects. Here, the efficacy and side-effect profile of 5αTHB were compared with hydrocortisone in preclinical models of irritant dermatitis.

中文翻译：

5α-四氢皮质酮：一种局部抗炎糖皮质激素，可改善小鼠皮炎模型的治疗指数

糖皮质激素是强效抗炎药，但有许多副作用。特应性皮炎的局部应用会导致皮肤变薄、代谢变化和肾上腺抑制。 5α-四氢皮质酮 (5αTHB) 是一种潜在的选择性抗炎药，可降低代谢作用。在此，在刺激性皮炎的临床前模型中比较了 5αTHB 与氢化可的松的疗效和副作用。

更新日期：2023-11-21

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南