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POCl3/Sulfoxide-Promoted Synthesis of Indolizino[8,7-b]indoles
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-11-20 , DOI: 10.1021/acs.joc.3c01912 Xiao-Hui Chen 1 , Yun-Meng Li 1 , Xiang Huang 1, 2 , Hai-Lei Cui 1
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-11-20 , DOI: 10.1021/acs.joc.3c01912 Xiao-Hui Chen 1 , Yun-Meng Li 1 , Xiang Huang 1, 2 , Hai-Lei Cui 1
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A mild chlorocyclization of pyrrole-tethered indoles has been realized using POCl3 as the chlorine source and tetramethylene sulfoxide as the promoter. A variety of chlorinated indolizino[8,7-b]indole derivatives have been constructed efficiently under this reaction system in moderate to good yields (19 examples, up to 93% yield).
中文翻译：
POCl3/亚砜促进吲哚嗪并[8,7-b]吲哚的合成
使用POCl 3作为氯源和四亚甲基亚砜作为促进剂，实现了吡咯系吲哚的温和氯环化。在此反应体系下，多种氯化中氮茚并[8,7- b ]吲哚衍生物被高效构建，收率中等至良好（19个实例，收率高达93%）。
更新日期：2023-11-20
中文翻译：
POCl3/亚砜促进吲哚嗪并[8,7-b]吲哚的合成
使用POCl 3作为氯源和四亚甲基亚砜作为促进剂，实现了吡咯系吲哚的温和氯环化。在此反应体系下，多种氯化中氮茚并[8,7- b ]吲哚衍生物被高效构建，收率中等至良好（19个实例，收率高达93%）。
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