<br>健康婴儿、儿童和青少年的完整 FGF23 浓度以及 X 连锁低磷血症性佝偻病患者的诊断价值,Journal of Endocrinological Investigation

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健康婴儿、儿童和青少年的完整 FGF23 浓度以及 X 连锁低磷血症性佝偻病患者的诊断价值
Journal of Endocrinological Investigation ( IF 3.9 ) Pub Date : 2024-04-01 , DOI: 10.1007/s40618-023-02202-4
G I Baroncelli ₁ , M R Sessa ₂ , C Pelosini ₂ , S Bertelloni ₁ , A Michelucci ₃ , B Toschi ₄ , P Piaggi _{5,

6} , D Peroni ₇ , P Comberiati ₇

Affiliation

抽象的

客观的

FGF23 测量可能对调查磷酸盐紊乱患者具有诊断作用。然而，婴儿、儿童和青少年的正常值尚未确定。

方法

总共 282 名（男性 145 名，女性 137 名）健康婴儿（ n = 30）、青春期前（ n = 147）、青春期（ n = 59）和青春期后（ n = 46）以及 20 名 X 连锁患者测量低磷血症性佝偻病（XLH，年龄 10.2 ± 5.6 岁）血清磷酸盐（自动分析仪）和血浆完整 FGF23（免疫化学发光夹心测定法，DiaSorin）浓度。

结果

健康婴儿的完整 FGF23 浓度高于青春期前 ( P < 0.01) 和青春期后受试者 ( P < 0.05)；青春期受试者比青春期后受试者表现出更高的值（ P <0.05）。健康婴儿的血清磷酸盐浓度高于青春期前、青春期和青春期后受试者（ P < 0.001）。青春期受试者的血清磷酸盐浓度高于青春期后受试者（ P < 0.001）。完整 FGF23 和血清磷酸盐浓度在性别、初潮年龄和初潮后时间方面没有差异 ( P = NS)。在健康受试者中，完整 FGF23 和血清磷酸盐浓度之间没有相关性。根据实际年龄和青春期发育情况，XLH 患者的完整 FGF23 浓度高于健康受试者 ( P < 0.0001)。在所有患者中，完整 FGF23 浓度均高于 40 pg/mL；完整 FGF23 浓度与血清磷酸盐浓度呈负相关（ r = -0.65； P < 0.01）。

结论

在健康受试者中，实际年龄和青春期是完整 FGF23 浓度的主要决定因素。完整的 FGF23 浓度可能是儿科患者早期诊断 XLH 的有用标志物。

"点击查看英文标题和摘要"

Intact FGF23 concentration in healthy infants, children, and adolescents, and diagnostic usefulness in patients with X-linked hypophosphatemic rickets

Abstract

Objective

FGF23 measurement may have a diagnostic role to investigate patients with phosphate disorders. However, normal values for infants, children, and adolescents have not been defined.

Methods

In a total of 282 (males 145, females 137) healthy infants (n = 30), prepubertal (n = 147), pubertal (n = 59), and postpubertal (n = 46), and in twenty patients with X-linked hypophosphatemic rickets (XLH, age 10.2 ± 5.6 years) serum phosphate (automated analyzer), and plasma intact FGF23 (immunochemiluminescent sandwich assay, DiaSorin) concentrations were measured.

Results

Intact FGF23 concentrations were higher in healthy infants than in prepubertal (P < 0.01) and postpubertal subjects (P < 0.05); pubertal subjects showed higher values (P < 0.05) than postpubertal subjects. Serum phosphate concentrations were higher (P < 0.001) in healthy infants than in prepubertal, pubertal, and postpubertal subjects. Pubertal subjects had higher (P < 0.001) serum phosphate concentrations than postpubertal subjects. Intact FGF23 and serum phosphate concentrations did not differ (P = NS) by sex, age of menarche, and time after menarche. In healthy subjects, there was no correlation between intact FGF23 and serum phosphate concentrations. Intact FGF23 concentrations were higher (P < 0.0001) in patients with XLH than in healthy subjects according to chronological age and pubertal development. In all patients, intact FGF23 concentrations were above 40 pg/mL; intact FGF23 concentrations were inversely correlated with serum phosphate concentrations (r = −0.65; P < 0.01).

Conclusion

In healthy subjects, chronological age and puberty were main determinants of intact FGF23 concentrations. Intact FGF23 concentrations may be a useful marker for the early diagnosis of XLH in pediatric patients.

更新日期：2024-03-28

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