We were delighted to read the article by Jarosova et al , which presents the results of a randomised controlled trial investigating the efficacy of endobiliary radiofrequency ablation (eRFA).1 The authors should be commended for conducting this large trial not only in pancreatic cancer but also, much rarer, perihilar cholangiocarcinoma (pCCA) patients. Endobiliary RFA uses high frequency current to generate heat, which results in coagulation and local tumour necrosis, possibly leading to delayed tumour growth. Theoretically, the potential benefit of eRFA is larger in tumours that originate from the bile duct itself rather than compressing the bile duct, such as pancreatic cancer. The safety and feasibility have been shown in multiple studies, but the efficacy has not been sufficiently studied in randomised trials yet.2–4 Unfortunately, current trial has not been able to show the superiority …

中文翻译：

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是时候关注胆管内射频消融的真正潜在益处了：胆管癌患者的支架通畅


我们很高兴阅读 Jarosova 等人的文章，其中介绍了一项随机对照试验的结果，该试验调查了胆内射频消融 (eRFA) 的功效。1 作者应该受到赞扬，因为他们不仅在胰腺癌方面进行了这项大型试验，而且在，更为罕见的是肝门周围胆管癌（pCCA）患者。胆内RFA利用高频电流产生热量，导致凝固和局部肿瘤坏死，可能导致肿瘤生长延迟。理论上，对于源自胆管本身而不是压迫胆管的肿瘤（例如胰腺癌），eRFA 的潜在益处更大。安全性和可行性已在多项研究中得到证明，但其功效尚未在随机试验中得到充分研究。2-4 不幸的是，目前的试验尚未能显示出优越性……