Hollow Cavity CaO2@Polydopamine Nanocomposites for pH-Responsive Ca2+-Enhanced Efficient Mild Hyperthermia in the NIR-II Region,Advanced Healthcare Materials

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Hollow Cavity CaO2@Polydopamine Nanocomposites for pH-Responsive Ca2+-Enhanced Efficient Mild Hyperthermia in the NIR-II Region
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-11-22 , DOI: 10.1002/adhm.202302634
Yue Wang ₁ , Shuqi Wang ₂ , Shanshan Li ₂ , Wenyao Zhen ₂ , Xiaodan Jia ₁ , Xiue Jiang _{1,

2}

Affiliation

Second near-infrared (NIR-II) mild photothermal therapy with higher tissue penetration depth and less damage to healthy tissues is emerging as an attractive antitumor modality, but its therapeutic efficiency is dramatically suppressed by the resistance of heat shock proteins (HSPs). As a widely explored photothermal agent, the application of polydopamine (PDA) in the NIR-II region is hampered by low photothermal conversion efficiency (PCE). Herein, its PCE in the NIR-II region is improved by developing novel hollow cavity CaO₂@PDA nanocomposites through chelation-induced diffusion of inner core Ca²⁺ to the shell PDA to facilitate multiple reflections of laser in the cavity. Upon pH-responsive degradation of CaO₂, its structure is transformed into a stacked “nano-mesh” with excellent light absorption and an enlarged effective irradiation area. Overloading of Ca²⁺ ions not only induces downregulation of HSPs but also enhances interference of light on membrane potential, which further aggravate mitochondrial dysfunction and reduce the thermotolerance of tumor cells, promoting efficient mild hyperthermia of PDA in the NIR-II region.

中文翻译：

中空腔 CaO2@聚多巴胺纳米复合材料用于 NIR-II 区域 pH 响应 Ca2+ 增强高效温和热疗

第二种近红外（NIR-II）温和光热疗法具有更高的组织穿透深度和对健康组织的损害更小，正在成为一种有吸引力的抗肿瘤方式，但其治疗效率受到热休克蛋白（HSP）的抵抗力的极大抑制。作为一种广泛探索的光热剂，聚多巴胺（PDA）在近红外-II区域的应用受到低光热转换效率（PCE）的阻碍。在此，通过开发新型中空腔CaO ₂ @PDA纳米复合材料，通过螯合诱导内核Ca ²⁺扩散到壳PDA以促进激光在腔内的多次反射，提高了其在NIR-II区域的PCE。 CaO ₂发生pH响应性降解后，其结构转变为堆叠的“纳米网”，具有优异的光吸收性和扩大的有效照射面积。 Ca ²⁺离子超载不仅诱导HSPs下调，而且增强光对膜电位的干扰，进一步加剧线粒体功能障碍，降低肿瘤细胞的耐热性，促进PDA在NIR-II区的高效温和热疗。

更新日期：2023-11-22

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