<br>木犀草素纳米级药物输送系统：进展和应用,Journal of Materials Chemistry B

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木犀草素纳米级药物输送系统：进展和应用
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-11-21 , DOI: 10.1039/d3tb01753b
Jinlu Shang _{1,

2} , Jing Yang _{1,

2} , Qinmin Deng ₂ , Meiling Zhou ₁

Affiliation

木犀草素 (Lu) 是一种天然存在的黄酮类化合物，具有多种药理活性，包括抗肿瘤、抗炎、抗菌和神经保护特性。然而，Lu的治疗效果和临床应用受到固有局限性的严重阻碍，例如水溶性差、半衰期短、生物利用度低和潜在的脱靶毒性。最近的研究表明，纳米载体的利用为增强Lu的溶解度、延长其循环时间和提高其靶向能力提供了一种有前途的策略。尽管过去几十年来有大量评论集中在Lu的来源、药理活性和分子机制上，但有关Lu负载纳米制剂及其应用的全面综述的文献中仍存在明显的空白。为了解决这一差距，我们对专门为 Lu 设计的纳米级药物输送系统的进展和应用进行了详尽的概述。这些平台包括胶束、基于纳米载体的系统、乳化药物递送系统和囊泡药物递送系统。我们提供有关合成材料、制备方法、理化性质以及与这些纳米制剂相关的重要结果的详细见解。这项系统综述对于在纳米递送策略领域寻求新途径并探索 Lu 的潜在临床应用的研究人员特别有价值。

"点击查看英文标题和摘要"

Nano-scale drug delivery systems for luteolin: advancements and applications

Luteolin (Lu) is a naturally occurring flavonoid compound with a diverse array of pharmacological activities, including anti-tumor, anti-inflammatory, antibacterial, and neuroprotective properties. However, the therapeutic efficacy and clinical application of Lu are significantly hindered by inherent limitations, such as poor water solubility, short half-life, low bioavailability, and potential off-target toxicity. Recent studies have demonstrated that the utilization of nanocarriers presents a promising strategy to enhance the solubility of Lu, prolong its circulation time, and improve its targeting ability. Despite numerous reviews over the past few decades having focused on the source, pharmacological activities, and molecular mechanisms of Lu, there exists a conspicuous gap in the literature regarding a comprehensive review of Lu-loaded nanoformulations and their applications. To address this gap, we present an exhaustive overview of the advancements and applications of nano-scale drug delivery systems specifically designed for Lu. These platforms encompass micelles, nanocarrier-based systems, emulsified drug delivery systems, and vesicular drug delivery systems. We provide detailed insights into the synthetic materials, preparation methods, physicochemical properties, and significant outcomes associated with these nanoformulations. This systematic review will be particularly valuable to researchers seeking novel avenues in the field of nano-delivery strategies and exploring the potential clinical applications of Lu.

更新日期：2023-11-22

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