PURPOSE Artery dysfunction is an early, integral stage in atherogenesis that predicts future cardiovascular events. Sedentary behaviour such as TV watching is highly prevalent and associated with increased risk of developing cardiovascular diseases. This study investigated whether patterns of TV watching throughout childhood and adolescence were associated with artery function in adulthood. METHODS TV watching data were collected when participants of the Raine Study were aged 5, 8, 10, 14, 17 and 20 years. Previous latent class analysis indicated 3 trajectory groups of TV watching: Low TV (<14 hrs/wk), High TV (>14 hrs/wk) and Increasing TV (change from Low TV to High TV). At age 28 yrs, participants were invited to undergo tests of brachial and femoral artery function by flow mediated dilation (FMD). General linear models examined differences in artery function between TV trajectory groups for males and females. RESULTS 560 participants (n = 261 female, n = 299 male) were included in the study. In females, the Low TV group had significantly greater femoral artery FMD (10.8 ± 1.6%) than both High TV (9.0 ± 1.3%, P = 0.005) and Increasing TV groups (8.5 ± 1.3%, P < 0.001); these results were maintained following mediation analysis including contemporaneous risk factors. There were no significant differences in femoral artery FMD between TV trajectory groups in males (P = 0.955). CONCLUSIONS This study suggests that TV watching behaviours during childhood and adolescence may have legacy impacts on artery function at age 28 yrs, particularly in females. This may increase the risk of atherosclerotic vascular pathologies in later life.

中文翻译：

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儿童期和青春期看电视与成年期动脉功能的关系。

目的 动脉功能障碍是动脉粥样硬化形成的早期、不可或缺的阶段，可预测未来的心血管事件。看电视等久坐行为非常普遍，并且与患心血管疾病的风险增加有关。这项研究调查了整个童年和青春期的电视观看模式是否与成年后的动脉功能相关。方法 收集 Raine 研究参与者 5、8、10、14、17 和 20 岁的电视观看数据。之前的潜在类别分析显示了 3 个电视观看轨迹组：低电视观看量（<14 小时/周）、高电视观看量（>14 小时/周）和增加电视观看量（从低电视观看量变为高电视观看量）。28 岁时，参与者被邀请通过血流介导扩张 (FMD) 进行肱动脉和股动脉功能测试。一般线性模型检查了男性和女性电视轨迹组之间动脉功能的差异。结果 560 名参与者（n = 261 名女性，n = 299 名男性）被纳入该研究。在女性中，低电视组的股动脉 FMD (10.8 ± 1.6%) 显着高于高电视组 (9.0 ± 1.3%，P = 0.005) 和增加电视组 (8.5 ± 1.3%，P < 0.001)；这些结果在包括同期风险因素在内的中介分析后得以维持。男性电视轨迹组之间股动脉 FMD 没有显着差异（P = 0.955）。结论 这项研究表明，儿童期和青春期的电视观看行为可能会对 28 岁时的动脉功能产生遗留影响，尤其是女性。这可能会增加晚年发生动脉粥样硬化血管病变的风险。