PURPOSE Using a replicated crossover design, we quantified the response heterogeneity of postprandial cardiovascular disease (CVD) risk marker responses to acute exercise. METHODS Twenty men (mean (SD) age, 26 (6) years; BMI, 23.9 (2.4) kg·m-2) completed four, 2-day conditions (two control, two exercise) in randomised orders. On days 1 and 2, participants rested and consumed two high-fat meals over 9-h. Participants ran for 60-mins (61 (7)% of peak oxygen uptake) on day 1 (6.5-7.5 h) of both exercise conditions. Time-averaged total-area-under-the-curve (TAUC) for triacylglycerol (TAG), glucose and insulin were calculated from 11 venous blood samples on day 2. Arterial stiffness and blood pressure responses were calculated from measurements at baseline on day 1 and at 2.5-h on day 2. Consistency of individual differences was explored by correlating the two replicates of control-adjusted exercise responses for each outcome. Within-participant covariate-adjusted linear mixed models quantified participant-by-condition interactions and individual-response SDs. RESULTS Acute exercise reduced mean TAUC-TAG (-0.27 mmol·L-1 h; Cohen's d = 0.29, P = 0.017) and TAUC-insulin (-24.45 pmol·L-1 h; Cohen's d = 0.35, P = 0.022) vs. control, but led to negligible changes in TAUC-glucose and the vascular outcomes (Cohen's d ≤ 0.41, P ≥ 0.106). Small-to-moderate, but nonsignificant, correlations were observed between the two response replicates (r = -0.40 to 0.15, P ≥ 0.066). We did not detect any individual response heterogeneity. All participant-by-condition interactions were P ≥ 0.137, and all individual-response SDs were small with wide 95% confidence intervals overlapping zero. CONCLUSIONS Large trial-to-trial within-subject variability inhibited detection of consistent inter-individual variability in postprandial metabolic and vascular responses to acute exercise.

中文翻译：

---

心血管疾病风险标志物对急性运动是否存在个体间反应？重复交叉研究。

目的使用重复交叉设计，我们量化了餐后心血管疾病（CVD）风险标志物对急性运动的反应异质性。方法 20 名男性（平均 (SD) 年龄，26 (6) 岁；BMI，23.9 (2.4) kg·m-2）以随机顺序完成四项为期 2 天的条件（两项对照，两项运动）。在第 1 天和第 2 天，参与者休息并在 9 小时内吃了两顿高脂肪餐。参与者在两种运动条件下的第一天（6.5-7.5 小时）跑了 60 分钟（峰值摄氧量的 61 (7)%）。根据第 2 天的 11 个静脉血样本计算三酰甘油 (TAG)、葡萄糖和胰岛素的时间平均总曲线下面积 (TAUC)。动脉僵硬度和血压反应根据第 1 天的基线测量值计算以及第 2 天 2.5 小时。通过关联每个结果的控制调整运动反应的两个重复，探索个体差异的一致性。参与者内协变量调整的线性混合模型量化了参与者与条件之间的相互作用和个体反应标准差。结果 急性运动降低平均TAUC-TAG（-0.27 mmol·L-1 h；Cohen's d = 0.29，P = 0.017）和TAUC-胰岛素（-24.45 pmol·L-1 h；Cohen's d = 0.35，P = 0.022）与对照相比，但导致 TAUC 葡萄糖和血管结果的变化可以忽略不计（Cohen's d ≤ 0.41，P ≥ 0.106）。在两个响应重复之间观察到小到中等但不显着的相关性（r = -0.40 至 0.15，P ≥ 0.066）。我们没有发现任何个体反应异质性。所有参与者与条件的交互作用均为 P ≥ 0.137，并且所有个体响应 SD 都很小，95% 置信区间与零重叠。结论 受试者内较大的试验间变异性抑制了餐后代谢和血管对急性运动反应的一致个体间变异性的检测。