Onygenaleosides A–F, 6/5 Bicyclic Ring Skeleton Triterpene Glycosides with Insecticidal Activity from Onygenales sp. YX1425,Journal of Natural Products

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Onygenaleosides A–F, 6/5 Bicyclic Ring Skeleton Triterpene Glycosides with Insecticidal Activity from Onygenales sp. YX1425
Journal of Natural Products ( IF 3.3 ) Pub Date : 2023-11-20 , DOI: 10.1021/acs.jnatprod.3c00243
Kang Chen ₁ , Jianshuang Zhou ₂ , Baoqing Dun _{2,

3} , Wenfei Zhang ₄ , Chen Wang _{1,

3} , Linan Xie _{1,

3} , Yuquan Xu _{1,

3}

Affiliation

Six new squalene derived polyether glycosides, onygenaleosides A–F (1–6), that possess a 6/5 bicyclic fused ring skeleton were isolated from the cultures of Onygenales sp. YX1425, along with two known analogues (7 and 8). The planar structures of the new compounds were elucidated based on analysis of NMR and MS spectroscopy data, and the absolute configuration of 1 was determined by the advanced Mosher method and quantum chemical calculations. Compound 2 was active against Spodoptera frugiperda with an LC₅₀ value of 193.4 ± 1.1 μg/mL.

中文翻译：

Onygenaleosides A–F，6/5 双环骨架三萜糖苷，来自 Onygenales sp.，具有杀虫活性。 YX1425

从Onygenales sp. 培养物中分离出六种新的角鲨烯衍生聚醚糖苷，onygenaleosides A–F ( 1 – 6 )，它们具有 6/5 双环稠合环骨架。 YX1425，以及两个已知的类似物（ 7和8 ）。基于NMR和MS光谱数据分析，阐明了新化合物的平面结构，并通过先进的Mosher方法和量子化学计算确定了1的绝对构型。化合物2对草地贪夜蛾具有活性，LC ₅₀值为 193.4 ± 1.1 μg/mL。

更新日期：2023-11-20

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