Self- and other-directed violence (SDV/ODV) contribute to elevated rates of mortality. Early trauma exposure shows robust positive associations with these forms of violence but alone does not distinguish those at heightened risk for later engagement in SDV/ODV. Novel assessment metrics could aid early identification efforts for individuals with vulnerabilities to violence perpetration. This study examined a novel neurobiological measure of impulsive choice for reward as a potential moderator of associations between childhood trauma exposure and lifetime SDV/ODV. A high-risk community sample of 177 adults (89 men; 50.3%) were assessed for childhood trauma exposure, engagement in SDV (e.g., suicide attempts), and ODV (e.g., assault). A cortical delay discounting (C-DD) measure was created using a multivariate additive model of gray matter thickness across both hemispheres, previously found to be positively associated with susceptibility to impulsivity and externalizing disorders. Childhood trauma exposure was positively associated with ODV and SDV; however, these relationships differed as a function of C-DD. Engagement in ODV increased as scores on C-DD increased, and SDV increased as scores on C-DD decreased. Furthermore, moderation revealed biological sex differences, as the association between childhood trauma and SDV depended on C-DD for women but not for men. Findings from the present work demonstrate that risk conferred by childhood trauma exposure to violence varied as a function of a C-DD. Together, these findings point to the utility of neurobiological markers of impulsive decision-making for differentiating risk for violence among individuals with a history of trauma exposure. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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皮质延迟贴现的神经生物学指标可以区分遭受创伤的个体发生自我暴力和他人暴力的风险。

自我暴力和他人暴力（SDV/ODV）导致死亡率升高。早期创伤暴露与这些形式的暴力行为表现出强烈的正相关性，但仅凭这一点并不能区分那些以后参与 SDV/ODV 的风险较高的人。新颖的评估指标可以帮助早期识别容易遭受暴力侵害的个人。这项研究检验了一种新的神经生物学测量方法，即奖励冲动选择作为童年创伤暴露与终生 SDV/ODV 之间关联的潜在调节因素。对 177 名成年人（89 名男性；50.3%）的高危社区样本进行了童年创伤暴露、参与 SDV（例如自杀未遂）和 ODV（例如攻击）的评估。使用两个半球灰质厚度的多元加性模型创建了皮质延迟贴现（C-DD）测量，之前发现该模型与冲动和外化障碍的易感性呈正相关。童年创伤暴露与 ODV 和 SDV 呈正相关；然而，这些关系因 C-DD 的函数而异。ODV 的参与度随着 C-DD 分数的增加而增加，SDV 的参与度随着 C-DD 分数的降低而增加。此外，适度揭示了生物性别差异，因为童年创伤和 SDV 之间的关联取决于女性的 C-DD，但不依赖于男性。目前的研究结果表明，儿童遭受暴力创伤所带来的风险随着 C-DD 的变化而变化。总之，这些发现表明冲动决策的神经生物学标记可用于区分有创伤暴露史的个体的暴力风险。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。