Herein, we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol. By simply changing the base, a broad range of structurally diverse ketones, could be selectively and efficiently converted to the corresponding -methylated secondary alcohols or secondary alcohols. Remarkably, this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols, as well as the three-component coupling between methyl ketones, primary alcohols, and methanol. The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

中文翻译：

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碱控 NHC-Ru 催化的甲醇转移氢化和酮的 α-甲基化/转移氢化

在此，我们报道了NHC-Ru催化剂系统，该系统实现了酮与甲醇的化学选择性转化。通过简单地改变碱基，多种结构多样的酮可以选择性且有效地转化为相应的甲基化仲醇或仲醇。值得注意的是，该催化系统对于生物相关分子和氘代醇的合成以及甲基酮、伯醇和甲醇之间的三组分偶联非常有效。通过实验和DFT机理研究进一步揭示了反应机理。