<br>ABLs 和 TMKs 是细胞外生长素的辅助受体,Cell

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ABLs 和 TMKs 是细胞外生长素的辅助受体
Cell ( IF 45.5 ) Pub Date : 2023-11-17 , DOI: 10.1016/j.cell.2023.10.017
Yongqiang Yu ₁ , Wenxin Tang ₂ , Wenwei Lin ₂ , Wei Li ₃ , Xiang Zhou ₄ , Ying Li ₂ , Rong Chen ₅ , Rui Zheng ₅ , Guochen Qin ₆ , Wenhan Cao ₇ , Patricio Pérez-Henríquez ₈ , Rongfeng Huang ₂ , Jun Ma ₂ , Qiqi Qiu ₉ , Ziwei Xu ₂ , Ailing Zou ₂ , Juncheng Lin ₂ , Liwen Jiang ₇ , Tongda Xu ₁ , Zhenbiao Yang ₁₀

Affiliation

Haixia Institute of Science and Technology, School of Future Technology, and College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China; Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, P.R. China.
Haixia Institute of Science and Technology, School of Future Technology, and College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China.
Haixia Institute of Science and Technology, School of Future Technology, and College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China; College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
Haixia Institute of Science and Technology, School of Future Technology, and College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China; Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, Guangdong 518055, P.R. China; Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, P.R. China.
Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, P.R. China.
Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, P.R. China; Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Weifang, Shandong 261000, P.R. China.
School of Life Sciences, Centre for Cell and Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, P.R. China.
Institute of Integrative Genome Biology, and Department of Botany and Plant Sciences, University of California-Riverside, Riverside, CA 92507, USA.
College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China.
Haixia Institute of Science and Technology, School of Future Technology, and College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China; Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, Guangdong 518055, P.R. China; Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, P.R. China; Institute of Integrative Genome Biology, and Department of Botany and Plant Sciences, University of California-Riverside, Riverside, CA 92507, USA.

生长素是植物中必需的植物激素，细胞外对生长素的感知已经争论了几十年。生长素结合蛋白 1 （ABP1）与典型的跨膜激酶（TMK）物理相互作用，并被提议充当细胞外生长素受体，但其作用存在争议，因为 abp1 敲除突变体缺乏明显的形态学表型。在这里，我们鉴定了两种新的生长素结合蛋白 ABL1 和 ABL2，它们定位于质外体，并以生长素依赖性方式直接与 TMK 的细胞外结构域相互作用。此外，功能互补的 ABL1 和 ABL2 与 TMK 遗传相互作用，并表现出与 ABP1 重叠的功能，并且独立于 ABP1。重要的是，TMK1 的胞外结构域本身结合生长素并与 ABP1 或 ABL1 协同结合生长素。因此，我们的研究结果发现生长素受体 ABL1 和 ABL2 具有与 ABP1 重叠但不同的功能，并与 TMKs 一起作为细胞外生长素的辅助受体发挥作用。

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更新日期：2023-11-17

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