原位生成的染料@MOF/COF异质结构通过不同发光通道荧光检测磷酸氯喹和叶酸,ACS Applied Materials & Interfaces

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原位生成的染料@MOF/COF异质结构通过不同发光通道荧光检测磷酸氯喹和叶酸
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-11-16 , DOI: 10.1021/acsami.3c11298
Xueping Quan ₁ , Bing Yan ₁

Affiliation

金属有机骨架（MOF）和共价有机骨架（COF）杂化材料可以结合MOF和COF组分的独特性能，其在荧光传感中的应用受到越来越多的关注。在此，ZIF-90通过简单的原位生长方法在3D-COF上生长，其中7-氨基-4-甲基香豆素(AMC)被封装在ZIF-90中以构建荧光传感器。磷酸氯喹(CQP)可与Zn ²⁺配合分解ZIF-90并释放AMC。在 365 nm 激发下，尿液中比率荧光信号 AMC/3D-COF ( I ₄₃₀ / I _{598 ) 在 4 × 10}^–5至 4 × 10 ^–4 M的线性范围内随 CQP 线性增加。在 340 nm 激发下，根据 Zn-CQP/3D-COF ( I ₃₈₄ / I ₅₉₈ ) 的荧光强度对血清中的 CQP（3 × 10 ^–6至 4 × 10 ^–5 M）进行定量分析。此外，AMC@ZIF-90/3D-COF ( 1 ) 在“关断”模式下的 FA 传感中表现出高抗干扰性和选择性，相关范围为 1 × 10 ^–5至 1 × 10 ^–3 M. CQP在不同激发条件下触发的荧光颜色变化，以及CQP引起的不同荧光响应，使其成为高度安全的防伪平台。合成的染料@MOF/COF杂化物不仅提供了一种集成多重发射来设计用于差异检测的荧光探针的新方法，而且为防伪平台的设计提供了思路。

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In Situ Generated Dye@MOF/COF Heterostructure for Fluorescence Detection of Chloroquine Phosphate and Folic Acid via Different Luminescent Channels

Metal-organic framework (MOF) and covalent-organic framework (COF) hybrid materials can combine the unique properties of MOF and COF components, and their applications in fluorescence sensing have attracted more and more attention. Herein, ZIF-90 is grown on 3D-COF by a simple in situ growing method in which the 7-amino-4-methylcoumarin (AMC) is encapsulated in ZIF-90 to construct a fluorescent sensor. Chloroquine phosphate (CQP) can coordinate with Zn²⁺ to decompose the ZIF-90 and release AMC. At 365 nm excitation, the ratiometric fluorescence signal AMC/3D-COF (I₄₃₀/I₅₉₈) increases linearly with CQP in a linear range of 4 × 10^–5 to 4 × 10^–4 M in urine. Under 340 nm excitation, quantitative analysis of CQP in the serum (3 × 10^–6 to 4 × 10^–5 M) is based on the fluorescence intensity of Zn-CQP/3D-COF (I₃₈₄/I₅₉₈). In addition, AMC@ZIF-90/3D-COF (1) exhibits high anti-interference and selectivity in sensing of FA with a “turn off” mode, with a correlation range of 1 × 10^–5 to 1 × 10^–3 M. The fluorescence color changes triggered by CQP under different excitation conditions, and the different fluorescence responses caused by CQP make it a highly secure anticounterfeiting platform. The synthesized dye@MOF/COF hybrids not only provide a new way to integrate multiple emission to design fluorescent probes for differentiation detection but also offer ideas for the design of anticounterfeiting platforms.

更新日期：2023-11-16

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