Analysis of drugs clinically and their identification in biological samples are of utmost importance in the process of therapeutic drug monitoring, also in pharmacokinetic investigations and tracking of illicit medications. These investigations are carried out using a variety of analytical methods, including potentiometric electrodes. Potentiometric electrodes are a wonderful solution for researchers because they outperform other methods in terms of sustainability, greenness, and cost effectiveness. In the current study, ion-selective potentiometric sensors were assembled for the aim of quantification of the anticancer drug Letrozole (LTZ). The first step was fabrication of a conventional sensor based on the formation of stable host–guest inclusion complex between the cationic drug and 4-tert-butylcalix-8-arene (TBCAX-8). Two additional sensors were prepared through membrane modification with graphene nanocomposite (GNC) and polyaniline (PANI) nanoparticles. Linear responses of 1.00 × 10^–5–1.00 × 10^–2, 1.00 × 10^–6–1.00 × 10^–2 and 1.00 × 10^–8–1.00 × 10^–3 with sub-Nernstian slopes of 19.90, 20.10 and 20.30 mV/decade were obtained for TBCAX-8, GNC, and PANI sensors; respectively. The developed sensors were successful in determining the drug LTZ in bulk powder and dosage form. PANI modified sensor was used to determine LTZ in human plasma with recoveries ranging from 88.00 to 96.30%. IUPAC recommendations were followed during the evaluation of the electrical performance of the developed sensors. Experimental conditions as temperature and pH were studied and optimized. Analytical Eco-scale and Analytical GREEness metric were adopted as the method greenness assessment tools.

临床药物分析及其在生物样品中的鉴定对于治疗药物监测过程以及药代动力学研究和非法药物追踪至关重要。这些研究是使用各种分析方法进行的，包括电位电极。电位电极对于研究人员来说是一个很好的解决方案，因为它们在可持续性、绿色性和成本效益方面优于其他方法。在当前的研究中，组装了离子选择性电位传感器，用于抗癌药物来曲唑（LTZ）的定量。第一步是基于阳离子药物和 4-叔丁基杯-8-芳烃 (TBCAX-8) 之间形成稳定的主客体包合物来制造传统传感器。另外两个传感器是通过石墨烯纳米复合材料（GNC）和聚苯胺（PANI）纳米颗粒的膜改性制备的。线性响应为 1.00 × 10 ^–5 –1.00 × 10 ^–2 、1.00 × 10 ^–6 –1.00 × 10 ^–2和 1.00 × 10 ^–8 –1.00 × 10 ^–3 ，亚能斯特斜率为 19.90、20.10 和 20.30 mV TBCAX-8、GNC 和 PANI 传感器获得了 /decade；分别。开发的传感器成功地测定了散装粉末和剂型中的药物 LTZ。 PANI 改良传感器用于测定人血浆中的 LTZ，回收率范围为 88.00 至 96.30%。在评估所开发的传感器的电气性能时遵循了 IUPAC 的建议。研究并优化了温度和pH等实验条件。采用分析型生态尺度和分析型绿色度指标作为绿色度评估工具。