Simply and Cheaply Prepared Liposomal Membrane for Nanocarriers: High Encapsulation Efficiency Based on Broad Regulation of Surface Charges and pH-Switchable Performance,Biomacromolecules

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Simply and Cheaply Prepared Liposomal Membrane for Nanocarriers: High Encapsulation Efficiency Based on Broad Regulation of Surface Charges and pH-Switchable Performance
Biomacromolecules ( IF 5.5 ) Pub Date : 2023-11-16 , DOI: 10.1021/acs.biomac.3c00679
Jiangjie Wu _{1,

2} , Xin Zhang _{1,

2} , Huili Yuan _{1,

2} , Sailong Wei _{1,

2} , Xiaokai Gu _{1,

2} , Yangfan Bu ₃ , Huiwen He _{1,

2} , Yanqin Shi _{1,

2} , Meng Ma _{1,

2} , Si Chen _{1,

2} , Xu Wang _{1,

2}

Affiliation

The zeta potential of nanoparticles impacts their distribution and metabolism in the body as well as their interaction with medications of varying charges, hence altering therapeutic efficacy and safety. In this paper, the external charges of liposomes were regulated by utilizing a simple and economical method based on competition for protons of cationic chitosan (CS) and anion hyaluronic acid (HA). The charge regulation of a liposomal membrane is generally accomplished by adjusting the ratio of charged lipids within a liposome (e.g., cationic DOTAP or anionic DOPS), the stability of which was maintained by the coating materials of cationic chitosan (CS) or anion hyaluronic acid (HA). A series of nanoparticles could respond to pH-stimulation with adjustable surface charge. Moreover, the sizes of liposomes coated with CS and HA remain within a narrow range. In vitro cytotoxicity tests revealed that the nanocarriers were safe, and the nanoparticles containing antitumor medicines were efficient in tumor therapy. Considering liposomes with different external surface charges could be aimed at diverse therapy purposes. The strategies for regulating liposomal surface charges with high encapsulation rates and certain release cycles reported here could provide a versatile platform as carriers for the delivery of drugs and other macromolecules into human bodies.

中文翻译：

简单、廉价地制备纳米载体脂质体膜：基于表面电荷的广泛调节和 pH 可调性能的高封装效率

纳米颗粒的 zeta 电位会影响它们在体内的分布和代谢，以及它们与不同电荷药物的相互作用，从而改变治疗效果和安全性。本文利用一种简单、经济的基于阳离子壳聚糖（CS）和阴离子透明质酸（HA）质子竞争的方法来调节脂质体的外电荷。脂质体膜的电荷调节一般是通过调节脂质体内带电脂质（如阳离子DOTAP或阴离子DOPS）的比例来实现，其稳定性通过阳离子壳聚糖（CS）或阴离子透明质酸的包衣材料来维持（哈）。一系列纳米颗粒可以通过可调节的表面电荷来响应 pH 值刺激。此外，CS和HA包被的脂质体的尺寸保持在一个狭窄的范围内。体外细胞毒性测试表明，纳米载体是安全的，并且含有抗肿瘤药物的纳米颗粒可有效治疗肿瘤。考虑具有不同外表面电荷的脂质体可以针对不同的治疗目的。本文报道的以高封装率和一定释放周期调节脂质体表面电荷的策略可以提供一个多功能平台作为将药物和其他大分子递送到人体的载体。

更新日期：2023-11-16

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