Cellular neurobiology of hyperforin,Phytotherapy Research

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Cellular neurobiology of hyperforin
Phytotherapy Research ( IF 6.1 ) Pub Date : 2023-11-14 , DOI: 10.1002/ptr.8063
Alexandre Bouron ₁

Affiliation

Hyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro-apoptotic, antiproliferative, and anti-inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential applications in neurology and psychiatry. For instance, hyperforin possesses antidepressant properties, impairs the uptake of neurotransmitters, and stimulates the brain derived neurotrophic factor (BDNF)/TrkB neurotrophic signaling pathway, the adult hippocampal neurogenesis, and the brain homeostasis of zinc. In fact, hyperforin is a multi-target biomolecule with a complex neuropharmacological profile. However, one prominent pharmacological feature of hyperforin is its ability to influence the homeostasis of cations such as Ca²⁺, Na⁺, Zn²⁺, and H⁺. So far, the pathophysiological relevance of these actions is currently unknown. The main objective of the present work is to provide an overview of the cellular neurobiology of hyperforin, with a special focus on its effects on neuronal membranes and the movement of cations.

中文翻译：

金丝桃素的细胞神经生物学

Hyperforin 是从药用植物贯叶连翘（圣约翰草，SJW）中分离出来的间苯三酚衍生物。这种亲脂性生物分子具有抗菌、促凋亡、抗增殖和抗炎活性。此外，体外和体内数据表明，金丝桃素是一种有前途的分子，在神经病学和精神病学方面具有潜在的应用前景。例如，金丝桃素具有抗抑郁特性，损害神经递质的摄取，并刺激脑源性神经营养因子 (BDNF)/TrkB 神经营养信号通路、成人海马神经发生和锌的大脑稳态。事实上，金丝桃素是一种具有复杂神经药理学特征的多靶点生物分子。然而，金丝桃素的一个显着药理学特征是它能够影响Ca ²⁺ 、Na ⁺ 、Zn ²⁺和H ⁺等阳离子的稳态。到目前为止，这些行为的病理生理学相关性尚不清楚。目前工作的主要目的是概述金丝桃素的细胞神经生物学，特别关注其对神经元膜和阳离子运动的影响。

更新日期：2023-11-17

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