Synthesis of β-Hydroxysulfides via Multi-Component Cascade Hydroxysulfenylation of Styrenes with NH4SCN and Water under Transition-metal-free Conditions,Chemistry - An Asian Journal

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Synthesis of β-Hydroxysulfides via Multi-Component Cascade Hydroxysulfenylation of Styrenes with NH4SCN and Water under Transition-metal-free Conditions
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2023-11-14 , DOI: 10.1002/asia.202300901
Xian Liu ₁ , Liqiang Hao ₁ , Yangyang Wang ₁ , Yafei Ji ₁

Affiliation

We have constructed β-hydroxysulfides through a multi-component reaction, resulting in the synthesis of 34 compounds with a maximum yield of 87 %. The reaction exhibited good substrate compatibility, simple operation, and cost-effectiveness with readily available starting materials. This holds promise for applications in the synthesis of bioactive molecules.

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