Recent Progress in Transition-Metal-Catalyzed Reductive Cross-Coupling Reactions Using Diboron Reagents as Reductants,ACS Catalysis

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Recent Progress in Transition-Metal-Catalyzed Reductive Cross-Coupling Reactions Using Diboron Reagents as Reductants
ACS Catalysis ( IF 11.3 ) Pub Date : 2023-11-16 , DOI: 10.1021/acscatal.3c04342
Shasha Geng ₁ , Chaoqun Shi ₁ , Bohao Guo ₁ , Haoran Hou ₁ , Zhengli Liu _{1,

2} , Zhang Feng _{1,

2}

Affiliation

Transition-metal-catalyzed reductive cross-coupling reactions have been developed as one of the important tools for constructing C–C bonds. These reactions involve the direct coupling of two distinct electrophiles promoted by transition metals and reductants. Notably, these methods offer advantages over conventional cross-coupling reactions because they circumvent the need for air- and moisture-sensitive organometallic reagents while being simple to operate and exhibiting good compatibility with various functional groups. In recent years, diboron reagents have gained prominence as reductants for reductive cross-coupling reactions alongside traditional metal reductants, such as Zn, Mn, and Mg. This Review aims to provide an insightful overview of nickel/copper/iron-catalyzed reductive coupling reactions using diboron reagents as reductants and illustrate their possible reaction mechanisms.

中文翻译：

以二硼试剂为还原剂的过渡金属催化还原交叉偶联反应的最新进展

过渡金属催化的还原交叉偶联反应已成为构建C-C键的重要工具之一。这些反应涉及过渡金属和还原剂促进的两种不同亲电子试剂的直接偶联。值得注意的是，这些方法比传统的交叉偶联反应具有优势，因为它们不需要对空气和湿度敏感的有机金属试剂，同时操作简单并且与各种官能团表现出良好的相容性。近年来，二硼试剂与传统金属还原剂（如锌、锰和镁）一起作为还原交叉偶联反应的还原剂而受到重视。本综述旨在对使用二硼试剂作为还原剂的镍/铜/铁催化还原偶联反应进行深入的概述，并说明其可能的反应机制。

更新日期：2023-11-16

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